Products of Conception, Ploidy by Flow Cytometry
2006178
Ordering Recommendation
 
Mnemonic
DNA HYDAT
Methodology
Quantitative Flow Cytometry
Performed
Sun, Tue
Reported
3-9 days  
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Products of conception in paraffin tissue block.  
Specimen Preparation
Paraffin embed products of conception in a tissue block   
Storage/Transport Temperature
Refrigerated  
Unacceptable Conditions
No tissue remaining on the block. Specimens fixed in Bouin's Solution (picric acid), fixatives containing mercuric chloride (e.g. B5, Zenker's solution) or ethanol-based fixatives containing ethylene glycol, acetic acid, or zinc chloride.  Decalcified specimens.  
Remarks
Include H&E stained slide and surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
   
Interpretive Data
Flow Cytometry can be used to help identify partial hydatidiform moles. Partial moles are usually triploid while complete moles are diploid or tetraploid. [Clinical Medicine: Pathology, 2008, 1:61-67]. However, most products of conception are diploid by flow cytometry, so a diploid histogram does not suggest a complete hydatidiform mole unless supported clinically and microscopically. Of 35 cases of histologically apparent partial moles, no complications occurred in those that were triploid. However, 20 percent of those that were diploid had complications (persistence, metastasis). [Am J Ob Gyn, 1987, 157: 969-73]

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
A thin section of each tissue submitted is stained with H&E. The DNA content is classified as diploid, triploid, tetraploid or aneuploid. The DNA index is the ratio of the DNA content of abnormal cells compared to normal cells.
CPT Code(s)
88182
Components
Component Test Code*Component Chart NameLOINC
0095737Source:31208-2
2006308POC - DNA Analysis30911-2
2008898POC - DNA Index30912-0
2010872EER DNA, POC11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • DNA Ploidy for Hydatidiform Moles
  • Partial and Complete Hydatidiform Moles
  • Partial or Complete Hydatidiform Moles
  • Products of Conception