DNA Content/Cell Cycle Analysis, Hydatidiform Mole
2006178
 
Ordering Recommendation
Mnemonic
DNA HYDAT
Methodology
Quantitative Flow Cytometry
Performed
Sun, Tue
Reported
3-9 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory.
Specimen Required
Patient Preparation
 
Collect
Hydatidiform mole tissue.  
Specimen Preparation
Paraffin embed tissue block with hydatidiform mole. If no normal tissue is included in the block, please supply a control tissue block to be processed in parallel.  
Storage/Transport Temperature
Refrigerated  
Unacceptable Conditions
No tissue remaining on the block. Specimens fixed in Bouin's Solution (picric acid), fixatives containing mercuric chloride (e.g. B5, Zenker's solution) or ethanol-based fixatives containing ethylene glycol, acetic acid, or zinc chloride. Decalcified specimens.  
Remarks
Include H&E stained slide and surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Interpretive Data
Flow Cytometry can be used to distinguish between partial and complete hydatidiform moles. Partial moles are usually triploid while complete moles are diploid or tetraploid. [Clinical Medicine: Pathology, 2008, 1:61-67]. Of the 35 cases of histologically apparent partial moles, no complication occurred in those that were triploid. However, 20 percent of those that were diploid had complications (persistence, metastasis). [Am J Ob Gyn, 1987, 157: 969-73]

See Compliance Statement B: www.aruplab.com/CS
Note
A thin section of each tissue submitted is stained with H&E. The DNA content is classified as diploid, triploid, tetraploid or aneuploid. The DNA index is the ratio of the DNA content of abnormal cells compared to normal cells.
CPT Code(s)
88182
Components
Component Test Code*Component Chart Name
0095737Source:
2006308DNA Content, Hydatidiform Mole
2008898DNA Index, Hydatidiform Mole
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • DNA Ploidy for Hydatidiform Moles (DNA Content/Cell Cycle Analysis, Hydatidiform Mole)
  • Partial or Complete Hydatidiform Moles (DNA Content/Cell Cycle Analysis, Hydatidiform Mole)