ALK Gene Rearrangements in NSCLC for Crizotinib Eligibility by FISH
2006102
 
Ordering Recommendation
Mnemonic
ALK GENE
Methodology
Fluorescence in situ Hybridization
Performed
Varies
Reported
7-10 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory.
Specimen Required
Patient Preparation
 
Collect
Tumor tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tumor tissue. Transport tissue block or 4 unstained, consecutively cut, 5-micron thick sections, mounted on positively charged glass slides. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.  
Unacceptable Conditions
 
Remarks
Include surgical pathology report with reason for referral. The laboratory will not reject specimens that arrive without a pathology report but will hold the specimen until this information is received.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Note
CPT Code(s)
88271 x2, 88274 (25-99), 88291
Components
Component Test Code*Component Chart Name
2006127ALK Gene Rearrangements in NSCL by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Lung Cancer, ALK (2p23) Rearrangement, FISH, Tissue
  • Lung Carcinoma
  • Non-Small Cell Lung Cancer
  • NSCLC
  • Soft-FLCA
Performed at Mayo