Streptococcus pneumoniae Antibodies, IgG (23 Serotypes)
2005779
Ordering Recommendation
 
Mnemonic
PNEUMO 23
Methodology
Quantitative Multiplex Bead Assay
Performed
Tue, Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube. Post-immunization specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of pre-immunization specimen.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) MARK SPECIMENS CLEARLY AS "PRE" OR "POST" SO SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY.  
Storage/Transport Temperature
Refrigerated. "Pre" and "post" pneumococcal vaccine specimens can be submitted separately or together for testing.  
Unacceptable Conditions
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles).  
Reference Interval
   
Interpretive Data
A pre-and post-vaccination sample comparison is required in order to assess the humoral immune response to vaccination with Streptococcus pneumoniae vaccine. Post vaccination samples should be obtained at 4 weeks post-immunization. A single sample provides only general immune status of an individual to various serotypes of pneumococci. Immune response to pneumococci may vary in different individuals based on the age, vaccination status, immunologic competence and the serotype of the organism. Long-term protection is generally considered to be a serotype antibody level of 1.3 µg/ mL or greater.

Following vaccination, an antibody ratio of less than twofold is considered a non-responder; a ratio of two-to fourfold is a weak responder; a ratio of fourfold or greater is a good responder. The higher the pre-vaccination antibody level for a specific pneumococcal serotype, the less likely the response will increase significantly after vaccination.

An increased antibody level to 50-70 percent or more of the serotypes is thought to represent a normal humoral response. In the case of pure polysaccharide vaccine, indication of immune system competence is further delineated as an adequate response to at least 70 percent of the serotypes in the vaccine challenge for those 6-65 years of age, or to at least 50 percent of the serotypes in the vaccine challenge for those 2-5 years of age.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
Includes Serotypes 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F. (Conjugated Serotypes: 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F.).

This assay is designed to use both pre- and post-immunization specimens to assess immune responsiveness to pneumococcal vaccine. This test is not designed to determine protection to Streptococcus pneumoniae based on a single specimen.
CPT Code(s)
86317 x23
Components
Component Test Code*Component Chart NameLOINC
0050706Pneumococcal Serotype 1 IgG27092-6
0050708Pneumococcal Serotype 4* IgG27094-2
0050709Pneumococcal Serotype 5 IgG31183-7
0050713Pneumococcal Serotype 6B* IgG27118-9
0050715Pneumococcal Serotype 3 IgG27096-7
0050716Pneumococcal Serotype 7F IgG25296-5
0050717Pneumococcal Serotype 9N IgG27392-0
0050718Pneumococcal Serotype 14* IgG27387-0
0050719Pneumo Serotype Interpretation42771-6
0050721Pneumococcal Serotype 8 IgG27113-0
0050722Pneumococcal Serotype 9V*, IgG30153-1
0050723Pneumococcal Serotype 12F IgG27374-8
0050724Pneumococcal Serotype 18C* IgG27395-3
0050726Pneumococcal Serotype 19F* IgG27390-4
0050727Pneumococcal Serotype 23F* IgG27389-6
2005780Pneumococcal Serotype 2 IgG40964-9
2005781Pneumococcal Serotype 10A IgG40967-2
2005782Pneumococcal Serotype 11A IgG40968-0
2005783Pneumococcal Serotype 15B IgG40973-0
2005784Pneumococcal Serotype 17F IgG40963-1
2005785Pneumococcal Serotype 19A IgG40974-8
2005786Pneumococcal Serotype 20 IgG40965-6
2005787Pneumococcal Serotype 22F IgG40966-4
2005788Pneumococcal Serotype 33F IgG40969-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • pneumo conjugate vaccine
  • Pneumo polysaccharide vaccine
  • S. Pneumoniae Vaccine
  • Strep Antibodies 23 serotypes
  • Strep Pneumo Antibodies
  • Strep Pneumoniae Antibody
  • Strep Vaccine