Streptococcus pneumoniae Antibodies, IgG (23 Serotypes)
2005779
Ordering Recommendation
Submit With Order
Mnemonic
PNEUMO 23
Methodology
Quantitative Multiplex Bead Assay
Performed
Tue
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. Post-immunization specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of pre-immunization specimen.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) MARK SPECIMENS CLEARLY AS "PRE" OR "POST" SO SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY.  
Storage/Transport Temperature
Refrigerated. "Pre" and "post" pneumococcal vaccine specimens can be submitted separately or together for testing.  
Unacceptable Conditions
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles).  
Reference Interval
Interpretive Data
A pre- and post- vaccination sample comparison is required in order to assess the humoral immune response to vaccination with Streptococcus pneumoniae vaccine. Post vaccination samples should be obtained at 4 weeks post-immunization. A single sample provides only general immune status of an individual to various serotypes of pneumococci. Immune response to pneumococci may vary in different individuals based on the age, vaccination status, immunologic competence and the serotype of the organism. Long-term protection is generally considered to be a serotype antibody level of 1.3 µg/ mL or greater.

Following vaccination, an antibody ratio of less than twofold is considered a non-responder; a ratio of two- to fourfold is a weak responder; a ratio of fourfold or greater is a good responder. The higher the pre-vaccination antibody level for a specific pneumococcal serotype, the less likely the response will increase significantly after vaccination.

An increased antibody level to 50-70 percent or more of the serotypes is thought to represent a normal humoral response. In the case of pure polysaccharide vaccine, indication of immune system competence is further delineated as an adequate response to at least 70 percent of the serotypes in the vaccine challenge for those 6-65 years of age, or to at least 50 percent of the serotypes in the vaccine challenge for those 2-5 years of age.

See Compliance Statement B: www.aruplab.com/CS
Note
Includes Serotypes 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F. (Conjugated Serotypes: 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F.).

This assay is designed to use both pre- and post-immunization specimens to assess immune responsiveness to pneumococcal vaccine. This test is not designed to determine protection to Streptococcus pneumoniae based on a single specimen.
CPT Code(s)
86317 x23
Components
Component Test Code*Component Chart Name
0050706Pneumococcal Serotype 1 IgG
0050708Pneumococcal Serotype 4* IgG
0050709Pneumococcal Serotype 5 IgG
0050713Pneumococcal Serotype 6B* IgG
0050715Pneumococcal Serotype 3 IgG
0050716Pneumococcal Serotype 7F IgG
0050717Pneumococcal Serotype 9N IgG
0050718Pneumococcal Serotype 14* IgG
0050719Pneumo Serotype Interpretation
0050721Pneumococcal Serotype 8 IgG
0050722Pneumococcal Serotype 9V*, IgG
0050723Pneumococcal Serotype 12F IgG
0050724Pneumococcal Serotype 18C* IgG
0050726Pneumococcal Serotype 19F* IgG
0050727Pneumococcal Serotype 23F* IgG
2005780Pneumococcal Serotype 2 IgG
2005781Pneumococcal Serotype 10A IgG
2005782Pneumococcal Serotype 11A IgG
2005783Pneumococcal Serotype 15B IgG
2005784Pneumococcal Serotype 17F IgG
2005785Pneumococcal Serotype 19A IgG
2005786Pneumococcal Serotype 20 IgG
2005787Pneumococcal Serotype 22F IgG
2005788Pneumococcal Serotype 33F IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • pneumo conjugate vaccine
  • Pneumo polysaccharide vaccine
  • S. Pneumoniae Vaccine
  • Strep Antibodies 23 serotypes
  • Strep Pneumo Antibodies
  • Strep Pneumoniae Antibody
  • Strep Vaccine