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Muscle Weakness Autoimmune Reflexive Panel
2005640
Ordering Recommendation
Acceptable reflexive panel for the differential diagnosis of acquired neuromuscular junction disorders. Panel contains binding, blocking, and modulating antibodies; voltage-gated calcium and potassium channels; titin antibody; and striated muscle antibodies.
Mnemonic
MUWA R PAN
Methodology
Quantitative Radioimmunoassay/Qualitative Radiobinding Assay/Semi-Quantitative Flow Cytometry/Semi-Quantitative Indirect Fluorescent Antibody
Performed
Refer to individual components
Reported
2-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube (SST).  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transport 2 mL serum. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Test Number
Components
Reference Interval
0080009Acetylcholine Receptor Binding AntibodyNegative: 0.0-0.4 nmol/L
Positive:  0.5 nmol/L or greater
0099580Acetylcholine Receptor Blocking AntibodyEffective November 18, 2013
Negative:0-26% blocking
Indeterminate:27-41% blocking
Positive:42% or greater blocking

0099521Acetylcholine Receptor Modulating AntibodyNegative: 0-45% modulating
Positive: 46% or greater modulating

Effective August 20, 2012
0092628Voltage-Gated Calcium Channel (VGCC) AntibodyEffective November 14, 2011
Negative0.0 to 24.5 pmol/L
Indeterminate24.6 to 45.6 pmol/L
Positive45.7 pmol/L or greater

2004890Voltage-Gated Potassium Channel (VGKC) AntibodyEffective April 18, 2011
Negative31 pmol/L or less
Indeterminate32-87 pmol/L
Positive88 pmol/L or greater

2005636Titin AntibodyEffective January 17, 2012
Titin Antibody
Negative0.00-0.45 IV
Indeterminate0.46-0.71 IV
Positive0.72 IV or greater

0050746Striated Muscle Antibodies, IgG with Reflex to TiterLess than 1:40

Interpretive Data
Refer to report.


Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
Note
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than 26 percent, then Acetylcholine Receptor Modulating Antibody will be added. If Striated Muscle Ab is detected, then a titer will be added. Additional charges apply.
CPT Code(s)
83519 x3; 83516 x2; 86255; if reflexed, add 83516 and/or 86256
Components
Component Test Code*Component Chart NameLOINC
0050747Striated Muscle Antibodies, IgG Screen49692-7
0080009Acetylcholine Binding Antibody11034-6
0092629Voltage-Gated Calcium Channel (VGCC) Ab31024-3
0099580Acetylcholine Blocking Antibody42937-3
2004890Voltage-Gated Potassium Channel (VGKC)Ab41871-5
2005637Titin Antibody
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AChR  Binding Antibody
  • AChR Antibody
  • Anti-Skeletal Muscle IgG Antibodies
  • Anti-Striated Antibody
  • anti-tintin Ab
  • Muscle (Skeletal) Antibodies
  • Muscle nicotinic Acetylcholine Receptor
  • Myasthenia Gravis Antibodies
  • Myoid Antibody
  • Skeletal Muscle Antibodies
  • Striational Antibodies
  • VGCC Ab
  • VGKC Ab
  • Voltage-Gated Calcium Channel Antibody
  • Voltage-Gated Potassium Channel Antibody