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Genomic SNP Microarray, Products of Conception
2005633
Ordering Recommendation

Indications for use
• Intrauterine fetal demise or stillbirth when further cytogenetic analysis is desired
• Pregnancy loss or termination in the presence of fetal anomalies
• Further characterization of fetal chromosomal abnormalities seen by conventional cytogenetic methods
• Multiple fetal losses of unknown etiology
• POC samples that fail to grow in culture

Mnemonic
ARRAY POC
Methodology
Genomic Microarray (Oligo-SNP Array)
Performed
Sun-Sat
Reported
2-3 weeks (Results requiring the completion of FISH testing may exceed the standard TAT)
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Cytogenetic Test Request Form Recommended (ARUP form #43097)Cytogenetic Test Request Form Recommended (ARUP form #43097)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container (Wide mouth containers: ARUP supply #42710) filled with tissue culture transport medium (ARUP Supply #32788). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers.
If autopsy is performed: Facia lata, diaphragm, tendon, skin, tissue from internal organs (if fresh), chest wall cartilage (particularly if macerated) or placenta from fetal side
If no autopsy is performed: Placenta from fetal side is preferred (e.g. villi).
Also acceptable: Umbilical cord or Achilles tendon. 
Specimen Preparation
Do not place in formalin. Transport products of conception (min: 5mg) in sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media. 
Storage/Transport Temperature
Room temperature (fresh tissue or culture flask). Also acceptable: Refrigerated or frozen. 
Unacceptable Conditions
Intact fetus. Specimens preserved in formalin. Specimens consisting of maternal tissue (decidua) only. Autolyzed or contaminated specimens. 
Remarks
If specimen collection time is greater than 72 hours, testing may be compromised. The laboratory will make every attempt to culture the specimen. Send specimen to lab for testing. This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Please submit the Patient History Form - Cytogenetics (Chromosome) Testing, Prenatal with the Electronic Packing List. The form is available on ARUP's Web site, http://www.aruplab.com/genetics/resources/patient-history. 
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Indefinitely 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing. Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up.
CPT Code(s)
81229
Components
Component Test Code*Component Chart NameLOINC
2005634SNP Microarray, Products of Conception62375-1
2005635EER SNP Microarray, Products of Concept11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • genomic microarray
  • oligo-SNP array