Endomysial Antibody, IgG
2005501
Ordering Recommendation
Use in IgA-deficient individuals; acceptable single screening test for celiac disease. Acceptable follow-up test for weakly positive or negative tissue transglutaminase IgG screen. Celiac Disease Reflexive Cascade (2008114) is the preferred screening test for individuals with high suspicion for IgA deficiency or patients at-risk for celiac disease who should undergo small bowel biopsy to confirm disease.
Mnemonic
EMA IGG
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Tue
Reported
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective November 14, 2011

Less than 1:10  
Interpretive Data
The presence of endomysial antibodies IgG, may be useful in identifying IgA-deficient patients at risk for celiac disease. To establish the diagnosis of celiac disease, a positive result must be confirmed through a biopsy of the small intestine.

See Compliance Statement D: www.aruplab.com/CS
Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
 
CPT Code(s)
86256
Components
Component Test Code*Component Chart Name
2005502Endomysial Antibody, IgG
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Aliases
  • Anti-Endomysial Antibodies
  • EMA
  • EMA IgG
  • Gluten-Sensitive Enteropathy Tests
  • IgA Deficient Celiac Disease