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High-Specificity Antiphospholipid Antibodies, IgG and IgM
2005457
Ordering Recommendation

Acceptable initial test when antiphospholipid syndrome (APS) is strongly suspected. More specific than cardiolipin IgG and IgM antibodies in the diagnosis of APS.

Mnemonic
HS APL
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, heat-inactivated, grossly hemolyzed, grossly icteric, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Available Separately
Components
Reference Interval
NoHigh-SpecificityAntiphospholipid Antibody, IgG14 GPL or less: Negative
15-26 GPL: Indeterminate - Repeat testing in 12 weeks
27 GPL or greater: Positive
NoHigh-SpecificityAntiphospholipid Antibody, IgM14 MPL or less: Negative
15-37 MPL: Indeterminate - Repeat testing in 12 weeks
38 MPL or greater: Positive

Interpretive Data
High-specificity antiphospholipid IgG and IgM antibodies are directed against a mixture of phosphatidylserine, phosphatidic acid, and beta-2 glycoprotein 1 antigens. These antibodies are more specific than cardiolipin IgG and IgM antibodies in the diagnosis of antiphospholipid syndrome (APS).


Note
GPL = IgG phospholipid units; MPL = IgM phospholipid units
CPT Code(s)
83516 x2
Components
Component Test Code*Component Chart NameLOINC
2005458High-Specificity Antiphospholipid Ab IgG7801-4
2005459High-Specificity Antiphospholipid Ab IgM7802-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • APS-HS