High-Specificity Antiphospholipid Antibodies, IgG and IgM
Acceptable initial test for strong suspicion of antiphospholipid syndrome (APS).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Sun, Tue, Thu
New York DOH Approval Status
This test is New York DOH approved.
- Patient Preparation
- Serum separator tube.
- Specimen Preparation
- Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Contaminated, heat-inactivated, grossly hemolyzed, grossly icteric, or severely lipemic specimens.
- After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen 1 year (avoid repeated freeze/thaw cycles)
|Available Separately||Components||Reference Interval|
|No||High-SpecificityAntiphospholipid Antibody, IgG||14 GPL or less: Negative|
15-26 GPL: Indeterminate-Repeat testing in 12 weeks
27 GPL or greater: Positive
|No||High-SpecificityAntiphospholipid Antibody, IgM||14 MPL or less: Negative|
15-37 MPL: Indeterminate-Repeat testing in 12 weeks
38 MPL or greater: Positive
High-specificity antiphospholipid IgG and IgM antibodies are directed against a mixture of phosphatidylserine, phosphatidic acid, and beta-2 glycoprotein 1 antigens. These antibodies are more specific than cardiolipin IgG and IgM antibodies in the diagnosis of antiphospholipid syndrome (APS).
GPL = IgG phospholipid units; MPL = IgM phospholipid units
83516 x 2
|Component Test Code*||Component Chart Name|
|2005458||High-Specificity Antiphospholipid Ab IgG|
|2005459||High-Specificity Antiphospholipid Ab IgM|