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Chromatin Antibody, IgG
2005287
Ordering Recommendation

Aids in the diagnosis of systemic lupus erythematosus (SLE).

Mnemonic
CHROMATIN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
19 Units or less: Negative
20-60 Units: Moderate Positive
61 Units or greater: Strong Positive
Interpretive Data
The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematosus (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis, especially when antibody levels are high.


Note
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
2005288Chromatin Antibody, IgG32580-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Chromatin
  • Anti-DNP
  • Anti-Nucleosome
  • Antichromatin
  • Antinucleosome
  • Chromatin Antibodies
  • chromatin IgG Ab
  • H2A-H2B-H3-H4
  • LE-Cell Factor
  • Nucleosome