Chromatin Antibody, IgG
2005287
Ordering Recommendation
Aids in the diagnosis of SLE.
Mnemonic
CHROMATIN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Wed
Reported
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Effective July 18, 2011
 
19 Units or less Negative
20-​60 Units Moderate Positive
61 Units or greater Strong Positive
Interpretive Data
The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematosus (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis, especially when antibody levels are high.  
Note
 
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
2005288Chromatin Antibody, IgG32580-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Chromatin
  • Anti-DNP
  • Anti-Nucleosome
  • Antichromatin
  • Antinucleosome
  • Chromatin Antibodies
  • chromatin IgG Ab
  • H2A-H2B-H3-H4
  • LE-Cell Factor
  • Nucleosome