N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer
2005164
Ordering Recommendation
Confirm diagnosis of anti-NMDAR encephalitis.
Mnemonic
NMDA G CSF
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Tue, Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
CSF.  
Specimen Preparation
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
  
Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective May 21, 2012
< 1:1  
Interpretive Data
Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.
CPT Code(s)
86255; if reflexed, add 86256
Components
Component Test Code*Component Chart Name
2005165N-methyl-D-Aspartate Receptor Ab, CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-NMDA CSF
  • Glutamate Receptor Antibodies
  • N-Methyl D-Aspartate Ab CSF
  • NMDA R
  • NMDA Receptor Ab CSF