- Patient Preparation
- New York State Clients: Testing is only approved for the Paroxysmal Nocturnal Hemoglobinuria Panel (ARUP test code 2005006) on whole blood specimens.
- Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
- Specimen Preparation
- Transport 4 mL whole blood. (Min: 4 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Clotted, hemolyzed or frozen specimens. Bone marrow specimens. Specimens older than 72 hours.
New York State Clients: Specimens for the PNH PAN older than 24 hours ambient or older than 48 hours refrigerated. Clotted, hemolyzed or frozen specimens. Bone marrow specimens.
- Specimens must be analyzed within 72 hours of collection.
New York State Clients: Only the whole blood PNH PAN is acceptable and must be analyzed within 24 hours of collection if ambient or 48 hours of collection if refrigerated.
- Ambient: 24 hours; Refrigerated: 72 hours; Frozen: Unacceptable
New York State Clients: PNH PAN-Ambient: 24 hours; Refrigerated: 48 hours. Frozen: Unacceptable
For initial diagnosis of PNH, Paroxysmal Nocturnal Hemoglobinuria Panel, RBC and WBC (ARUP test code 2005006) is available. This panel analyzes both RBCs and WBCs.
For delineation of RBC populations Types II and III when the PNH clone is 1 percent or greater, Paroxysmal Nocturnal Hemoglobinuria, High Sensitivity, RBC (ARUP test code 2004366) is available. This test also detects minor (0.005-0.999 percent) PNH clone populations found in bone marrow failure disorders.
|Component Test Code*||Component Chart Name||LOINC|
|2005004||% PNH Monocytes||60554-3|
|2005005||% PNH PMN||53831-4|
- CD15, CD33, CD14, CD24, FLAER
- Eculizumab treatment monitoring assay
- PI-Linked Antigens, Monocytes and Granulocytes