Screening test for Voltage-Gated Potassium Channel (VGKC) antibody receptor complex-associated autoantibodies. Assay does not identify Contactin Associated Protein 2 (CASPR2) Antibody or Leucine-rich Glioma Inactivated 1 Protein (LGI1) antibodies individually.
This test is New York DOH approved.
Voltage-Gated Potassium Channel (VGKC) antibodies are associated with neuromuscular weakness as found in neuromyotonia (also known as Issacs syndrome) and Morvan syndrome. VGKC antibodies are also associated with paraneoplastic neurological syndromes and limbic encephalitis; however, VGKC antibody-associated limbic encephalitis may be associated with antibodies to leucine-rich, glioma-inactivated 1 protein (Lgi1) or contactin-associated protein-2 (Caspr-2) instead of potassium channel antigens. The clinical significance of this test can only be determined in conjunction with the patient's clinical history and related laboratory testing.
See Compliance Statement D: www.aruplab.com/CS