Cytomegalovirus Antiviral Drug Resistance by Sequencing
2004760
 
Ordering Recommendation
Mnemonic
CMV RESIST
Methodology
Polymerase Chain Reaction/Sequencing
Performed
Sun-Sat
Reported
2-3 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA), pink (K2EDTA) or plasma preparation tube.  
Specimen Preparation
Separate plasma from cells within 8 hours. Transfer 4 mL plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Serum. Heparinized specimens.  
Remarks
Please submit most recent viral load and test date, if available.  
Stability
Ambient: 8 hours; Refrigerated: 72 hours; Frozen: 1 month  
Reference Interval
Interpretive Data
Codons 457-630 of the UL97 gene and codons 393-1000 of the UL54 gene are sequenced. Mutations associated with resistance to ganciclovir, cidofovir, and foscarnet are reported. Mutations in viral sub-populations below 20 percent of total may not be detected.

See Compliance Statement B: www.aruplab.com/CS
Note
This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma.
CPT Code(s)
87910
Components
Component Test Code*Component Chart Name
2004761CMV Cidofovir Resistance
2004762CMV Foscarnet Resistance
2004763CMV Ganciclovir Resistance
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • CMV
  • CMV Genotype
  • CMV Genotyping
  • CMV Resistance
  • CMV Resistance Genotype
  • CMV Resistance Sequencing
  • CMV Sequencing
  • CMV UL54
  • CMV UL54 Genotype
  • CMV UL97
  • CMV UL97 Genotype
  • CMV UL97/UL54 Genotype
  • Cytomegalovirus Resistance