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PAM50 Breast Cancer Intrinsic Classifier (INACTIVE as of 07/02/12)
2004700
Ordering Recommendation
Mnemonic
BRST TYPE
Methodology
Quantitative Reverse Transcription Polymerase Chain Reaction
Performed
Varies
Reported
12-14 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Tumor tissue. 
Specimen Preparation
Formalin fix (10% neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Ship in cooled container during summer months. . 
Storage/Transport Temperature
Room temperature or refrigerated. 
Unacceptable Conditions
Specimens with less than 75 percent tumor. Frozen specimens. Specimens fixed/processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). Decalcified specimens. 
Remarks
Surgical report requested. Direct punches may be required to complete testing. Client will be contacted for permission if a direct punch is required. Tissue block will be returned after testing. 
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
For more information see aruplab.com/PAM50.
CPT Code(s)
83907 Lysis; 83891 Isolation; 83902 Reverse transcription; 83898 x55 Amplification; 83912 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
Components
Component Test Code*Component Chart NameLOINC
2002148Block ID57723-9
2004701PAM50 Breast Subtype Classification
2004702PAM50 ESR1 Qualitative Score
2004703PAM50 ESR1 Quantitative Score
2004704PAM50 PGR Qualitative Score
2004705PAM50 PGR Quantitative Score
2004706PAM50 ERBB2 Qualitative Score
2004707PAM50 ERBB2 Quantitative Score
2004708PAM50 Breast Proliferation Score, Qual
2004709PAM50 Proliferation Score, Quantitative
2004710PAM50 Luminal Score, Qualitative
2004711PAM50 Luminal Score, Quantitative
2004713EER PAM50 Classifier, Breast Cancer
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Bioclassifier (PAM50 Breast Cancer Intrinsic Classifier)
  • Breast Cancer (PAM50 Breast Cancer Intrinsic Classifier)