Myelin Associated Glycoprotein (MAG) Antibodies, IgM and Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM
2004412
Ordering Recommendation
 
Mnemonic
MAG/SGPG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
 
 
Test Number Components Reference Interval
0051285Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
0051284Sulfate-​3-​Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV
Interpretive Data
An elevated IgM antibody concentration greater than 999 TU against myelin-associated glycoprotein (MAG) suggests active demyelination in peripheral neuropathy. A normal concentration (less than 999 TU) generally rules out an anti-MAG antibody-associated peripheral neuropathy.

The majority of sulfate-3-glucuronyl paragloboside (SGPG) IgM-positive sera will show reactivity against MAG. Patients who are SGPG IgM positive and MAG IgM negative may have multi-focal motor neuropathy with conduction block.

TU=Titer Units

See Compliance Statement D: www.aruplab.com/CS
Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
 
CPT Code(s)
83516 x2
Components
Component Test Code*Component Chart Name
0051284SGPG Antibody, IgM
0051285MAG Antibody, IgM Elisa
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • MAG and SGPG Antibodies
  • MAG Antibody Dual ELISA
  • MAG Dual Antigen
  • MAG IgM
  • Myelin Assoc. Glycoprotein (MAG) Antibody w/Reflex to MAG-SGPG & MAG, EIA
  • SGPG IgM
  • SGPG MAG Ab