Myelin Associated Glycoprotein (MAG) Antibodies, IgM and Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM
2004412
Ordering Recommendation
Submit With Order
Mnemonic
MAG/SGPG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Test Number Components Reference Interval
0051285Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
0051284Sulfate-​3-​Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV
Interpretive Data
An elevated IgM antibody concentration greater than 999 TU against myelin-associated glycoprotein (MAG) suggests active demyelination in peripheral neuropathy. A normal concentration (less than 999 TU) generally rules out an anti-MAG antibody-associated peripheral neuropathy.

The majority of sulfate-3-glucuronyl paragloboside (SGPG) IgM-positive sera will show reactivity against MAG. Patients who are SGPG IgM positive and MAG IgM negative may have multi-focal motor neuropathy with conduction block.

TU=Titer Units

See Compliance Statement D: www.aruplab.com/CS
Note
CPT Code(s)
83516 x2
Components
Component Test Code*Component Chart Name
0051284SGPG Antibody, IgM
0051285MAG Antibody, IgM Elisa
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • MAG and SGPG Antibodies
  • MAG Antibody Dual ELISA
  • MAG Dual Antigen
  • MAG IgM
  • Myelin Assoc. Glycoprotein (MAG) Antibody w/Reflex to MAG-SGPG & MAG, EIA
  • SGPG IgM
  • SGPG MAG Ab