Leukocyte Adhesion Deficiency Panel
2004359
Ordering Recommendation
 
Mnemonic
LAD PAN
Methodology
Semi-Quantitative Flow Cytometry
Performed
Sun-Sat
Reported
1-3 days  
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Green (sodium or lithium heparin).  
Specimen Preparation
Transport 5 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Clotted specimens. Frozen or room temperature specimens.  Specimens greater than 48 hours.  
Remarks
Client must supply a CBC and a differential with the whole blood specimen. The differential must include eosinophil and basophil counts. Specimen must be analyzed within 48 hours of collection.  
Stability
Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
Effective August 20, 2012
 
Available Separately Component Reference Interval
No %  CD11b 93-​100%
No %  CD15 91-​100%
No %  CD18 98-​100%
Interpretive Data
The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

See Compliance Statement A: www.aruplab.com/CS
Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
 
Note
 
CPT Code(s)
86356 x3
Components
Component Test Code*Component Chart NameLOINC
0095818% CD1838170-7
0095922% CD11b17110-8
0095957% CD1520590-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Beta 2 integrins
  • CD11b; CD15; CD18
  • LAD I, II determination