Leukocyte Adhesion Deficiency Panel
2004359
 
Ordering Recommendation
Mnemonic
LAD PAN
Methodology
Semi-Quantitative Flow Cytometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory.
Specimen Required
Patient Preparation
 
Collect
Green (sodium or lithium heparin).  
Specimen Preparation
Transport 5 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Clotted specimens. Frozen or room temperature specimens. Specimens greater than 48 hours.  
Remarks
Client must supply a CBC and a differential with the whole blood specimen. The differential must include eosinophil and basophil counts. Specimen must be analyzed within 48 hours of collection.  
Stability
Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
Effective August 20, 2012
Available Separately Component Reference Interval
No % CD11b 93-​100%
No % CD15 91-​100%
No % CD18 98-​100%
Interpretive Data
The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

See Compliance Statement A: www.aruplab.com/CS
Note
CPT Code(s)
86356 x3
Components
Component Test Code*Component Chart Name
0095818% CD18
0095922% CD11b
0095957% CD15
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References