N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer
2004221
Ordering Recommendation
Confirm diagnosis of NMDAR antibody encephalitis.
Mnemonic
NMDA IGG
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Tue, Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
CSF or plasma. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective May 21, 2012
< 1:10  
Interpretive Data
Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.  
Note
If NMDA antibody IgG is positive, then an NMDA antibody IgG titer is reported. Additional charges apply.
CPT Code(s)
86255; if reflexed, add 86256
Components
Component Test Code*Component Chart Name
2004222N-methyl-D-Aspartate Receptor Ab, Serum
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-NMDA
  • Glutamate Receptor Antibodies
  • N-Methyl D-Aspartate Ab
  • NMDA R
  • NMDA Receptor Ab
  • NMDA Reflex
  • NMDA Titer