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Alpha-1-Antitrypsin (AAT) by Immunohistochemistry
2003424
Ordering Recommendation

Aids in histologic diagnosis of Alpha-1-Antitrypsin deficiency.

Mnemonic
A1 AT IHC
Methodology
Immunohistochemistry
Performed
Mon-Fri
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Immunohistochemistry Stain Form Recommended  (ARUP form #32978)Immunohistochemistry Stain Form Recommended (ARUP form #32978)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Tissue or cells. 
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 2 slides). If sending precut slides, do not oven bake. 
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months. 
Unacceptable Conditions
Specimens submitted with non-representative tissue type. Depleted specimens. 
Remarks
IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. If you do not have electronic ordering capability, use an ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. For additional technical details, contact ARUP Client Services at (800) 522-2787. 
Stability
Ambient: Indefinitely, Refrigerated: Indefinitely, Frozen: Unacceptable 
Reference Interval
Interpretive Data


Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
All stains will be handled as "Stain and Return" unless a consultation is requested. To request a consultation, submit the pathology report, all associated case materials (clinical history, blocks, slides, etc.), and the Anatomic Pathology requisition form (form # 32960) in place of the Immunohistochemistry Stain Form.
Components
Component Test Code*Component Chart NameLOINC
2003425A1 AT by IHC
2003426A1 AT Reference Number
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • A1A IHC
  • A1AD
  • A1AT
  • A1AT Antibody Staining
  • A1AT IHC
  • AAT
  • AAT Antibody Staining
  • AAT IHC
  • Alpha 1 Antitrypsin IHC
  • Anti-Alpha-1-Trypsin IHC