Interferon Beta Neutralizing Antibody with Reflex to Titer
2003390
Ordering Recommendation
Aids in management of individuals treated with interferon beta.
Mnemonic
IFNB NEU R
Methodology
Cell Culture/Chemiluminescent Immunoassay
Performed
Thu
Reported
1-15 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Collect specimens before Interferon beta treatment, or more than 48 hours following the most recent dose. Patient should not be on steroid therapy in excess of 10 mg prednisolone (or equivalent) daily. High endogenous levels of Interferon beta, alpha, or gamma may interfere with this assay.  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, hemolyzed, icteric, or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
Available Separately  Components Reference Interval
 Interferon Beta Screen Negative
 Interferon Beta Titer Less than 20: Negative
20 to 99: Moderate levels of neutralizing antibodies present
100 or greater: High levels of neutralizing antibodies present
Interpretive Data
A titer of 20 to 99 suggests moderate levels of neutralizing antibodies present. A titer of 100 or greater suggests high levels of neutralizing antibodies present. Either case warrants continued patient monitoring. The titer is reported as the reciprocal of the dilution of patient serum that reduces the interferon activity by 10 fold.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
If Interferon Beta Neutralizing Antibody screen result is positive, then Interferon Beta Neutralizing Antibody titer will be added. 

This test is performed pursuant to an agreement with Biomonitor.
CPT Code(s)
86352; if reflexed, add 86352
Components
Component Test Code*Component Chart Name
2003391Interferon Beta Neutralizing Ab Screen
2003392Interferon Beta Neutralizing Ab Titer
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • iLite
  • Interferon-Beta
  • NAb
  • NabFeron
  • Neutralization