von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis
Ordering Recommendation
Recommended reflex panel to diagnose and subclassify suspected von Willebrand disease.
Electrophoresis/Western Blot/Clotting/Microlatex Particle-Mediated Immunoassay/Platelet Agglutination
1-11 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Lt. blue (sodium citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 3 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Clotted. Non-frozen or hemolyzed specimens.  
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months  
Reference Interval
Available Separately Components Reference Interval
0092281von Willebrand Factor Multimers By report
0030095Factor VIII, Activity 0-​6 years: 56-​191%
7-​9 years: 76-​199%
10-​11 years: 80-​209%
12-​13 years: 72-​198%
14-​15 years: 69-​237%
16-​17 years: 63-​221%
18 years and older: 56-​191%
0030285von Willebrand Factor Antigen 0-​6 years: 52-​214%
7-​9 years: 62-​180%
10-​11 years: 63-​189%
12-​13 years: 60-​189%
14-​15 years: 57-​199%
16-​17 years: 50-​205%
18 years and older: 52-​214%
0030250von Willebrand Factor Activity (Ristocetin Cofactor) 0-​6 years: 51-​215%
7-​9 years: 52-​176%
10-​11 years: 60-​195%
12-​13 years: 50-​184%
14-​15 years: 50-​203 %
16-​17 years: 49-​204%
18 years and older: 51-​215%
Interpretive Data
If von Willebrand ristocetin cofactor (RCF) or von Willebrand factor antigen (vWF Ag) or Factor VIII is low, von Willebrand Multimeric Analysis testing will be added.  If the ratio of RCF/vWF Ag is less than 0.7, vW Multimeric Analysis testing will be added.
CPT Code(s)
85240 F8; 85246 vWF/AG; 85245 RCF; If reflexed add 85247 vW Multi
Component Test Code*Component Chart NameLOINC
0030095Factor VIII, Activity3209-4
0030250von Willebrand Factor, Activity (RCF)6014-5
0030285von Willebrand Factor, Antigen27816-8
2003388von Willebrand Factor, RCF/Ag Ratio 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Coag
  • von Willebrand Profile