Protein C, Functional with Reflex to Protein C, Total and Protein S, Free with Reflex to Protein S, Total
2003386
Ordering Recommendation
Acceptable panel to detect and subtype protein C and S deficiencies. Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.
Submit With Order
Mnemonic
PROT C/S R
Methodology
Clotting/Enzyme-Linked Immunosorbent Assay/Microlatex Particle-Mediated Immunoassay
Performed
Mon-Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 4 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Non-frozen or hemolyzed specimens. Anticoagulants other than citrate.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
Available Separately Components Reference Interval
0030113Protein C, Functional 1-​4 days: 17-​53%
5-​29 days: 20-​64%
30-​89 days: 21-​65%
90-​179 days: 28-​80%
180-​364 days: 37-​81%
1-​6 years: 40-​92%
7-​9 years: 56-​144%
10-​11 years: 59-​143%
12-​13 years: 57-​142%
14-​15 years: 56-​162%
16-​17 years: 68-​154%
18 years and older: 77-​173%
0030111Protein C, Total Antigen 1-​4 days: 17-​53%
5-​29 days: 20-​64%
30-​89 days: 21-​65%
90-​179 days: 28-​80%
180-​364 days: 37-​81%
1-​5 years: 40-​92%
6-​10 years: 45-​93%
11 years and older: 63-​153%
0098894Protein S Free, Antigen 1-​89 days: 15-​55%
90-​179 days: 35-​92%
180-​364 days: 45-​115%
1-​5 years: 62-​120%
6-​9 years: 62-​130%
10-​17 years: 60-​140%
18 years and older Male: 74-​147%
18 years and older Female: 55-​123%
0030112Protein S, Total Antigen 1-​4 days: 12-​60%
5-​29 days: 22-​78%
30-​89 days: 33-​93%
90-​179 days: 54-​118%
180-​364 days: 55-​119%
1-​5 years: 54-​118%
6-​10 years: 41-​114%
11 years and older: Females: 63-​126%; Males: 84-​134%
Interpretive Data
Refer to report.
Note
If Protein C Functional is low, Protein C, Total Antigen will be added. If Protein S Free is low, Protein S Total Antigen will be added. Additional charges apply.
CPT Code(s)
85303; 85306; if reflexed add 85302; if reflexed, add 85305
Components
Component Test Code*Component Chart Name
0030113Protein C Functional
0098894Protein S Ag Free
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Protein C, Functional and Protein S Free