Protein C, Functional with Reflex to Protein C, Total and Protein S, Free with Reflex to Protein S, Total
2003386
Ordering Recommendation
Acceptable panel to detect and subtype protein C and S deficiencies. Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
PROT C/S R
Methodology
Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay/Microlatex Particle-Mediated Immunoassay
Performed
Mon-Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 4 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
 
 
Available Separately Components Reference Interval
0030113Protein C, Functional Effective November 17, 2014
 
Age Reference Interval
1-​4 days 17-​53%
5-​29 days 20-​64%
30-​89 days 21-​65%
90-​179 days 28-​80%
180-​364 days 37-​81%
1-​6 years 40-​92%
7-​9 years 70-​142%
10-​11 years 68-​143%
12-​13 years 66-​162%
14-​15 years 69-​170%
16-​17 years 70-​171%
18 years and older 83-​168%
0030111Protein C, Total Antigen 1-​4 days: 17-​53%
5-​29 days: 20-​64%
30-​89 days: 21-​65%
90-​179 days: 28-​80%
180-​364 days: 37-​81%
1-​5 years: 40-​92%
6-​10 years: 45-​93%
11 years and older: 63-​153%
0098894Protein S Free, Antigen  
 
Age Male Female
1-​89 days 15-​55% 15-​55%
90-​179 days 35-​92% 35-​92%
180-​364 days 45-​115% 45-​115%
1-​5 years 62-​120% 62-​120%
6-​9 years 62-​130% 62-​130%
10-​17 years 60-​140% 60-​140%
18 years and older 74-​147% 55-​123%
0030112Protein S, Total Antigen  
 
Age Male Female
1-​4 days 12-​60% 12-​60%
5-​29 days 22-​78% 22-​78%
30-​89 days 33-​93% 33-​93%
90-​179 days 54-​118% 54-​118%
180-​364 days 55-​119% 55-​119%
1-​5 years 54-​118% 54-​118%
6-​10 years 41-​114% 41-​114%
11 years and older 84-​134% 63-​126%
Interpretive Data
Refer to report.  
Note
If Protein C Functional is low, Protein C, Total Antigen will be added. If Protein S Free is low, Protein S Total Antigen will be added. Additional charges apply.
CPT Code(s)
85303; 85306; if reflexed add 85302; if reflexed, add 85305
Components
Component Test Code*Component Chart NameLOINC
0030113Protein C Functional27819-2
0098894Protein S Ag Free27821-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C, Functional and Protein S Free