Rheumatoid Arthritis Panel
Ordering Recommendation
Preferred panel for the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides.
Submit With Order
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Immunoturbidimetry
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Fasting specimen preferred.  
Serum separator tube.  
Specimen Preparation
Allow serum to clot completely at room temperature before centrifuging. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) Serum is the only acceptable specimen type for this assay without a disclaimer.  
Storage/Transport Temperature
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.  
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 weeks (avoid repeated freeze/thaw cycles)  
Reference Interval
Available Separately Components Reference Interval
0055256Cyclic Citrullinated Peptide (CCP) Antibody, IgG 19 Units or less: Negative
20-​39 Units: Weak positive
40-​59 Units: Moderate positive
60 Units or Greater: Strong positive
0050465Rheumatoid Factor 0-​14 IU/mL
Interpretive Data
Anti-cyclic citrullinated peptide (anti-CCP) IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.
CPT Code(s)
86200; 86431
Component Test Code*Component Chart Name
0050465Rheumatoid Factor
0055256Cyclic Citrullinated Peptide Ab, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • CCP and RF
  • RA Panel
  • RF and CCP IgG
  • Rheumatoid Arthritis Profile