Drug Detection Panel by High-Resolution Time-of-Flight Mass Spectrometry, Serum or Plasma
Ordering Recommendation
Preferred multidrug panel test for monitoring patient adherence. This is a high resolution test which eliminates need for secondary (confirmation) testing.
Qualitative Liquid Chromatography-Time of Flight Mass Spectrometry
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).  
Specimen Preparation
Remove plasma from cells ASAP or within 2 hours of collection. Transfer 4 mL plasma to an ARUP Standard Transport Tube. (Min: 2 mL) Also acceptable: Serum.  
Storage/Transport Temperature
Unacceptable Conditions
Specimens exposed to repeated freeze/thaw cycles. Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate).  
Cocaine and cocaethylene are more stable in fluoride-preserved plasma than serum.  
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years  
Reference Interval
Interpretive Data
Methodology: Qualitative Liquid Chromatography/-Time-of-Flight Mass Spectrometry

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration must be greater than or equal to the cutoff to be reported as present. If specific drug concentrations are required, contact the laboratory within two weeks of specimen collection to request confirmation and quantification by a second analytical technique.

For medical purposes only; not valid for forensic use.

Drugs covered and range of cutoff concentrations. Note that some drugs are identified based on the presence of unique drug metabolites not listed below.

Drugs/Drug Classes
Range of Cutoff Concentrations
buprenorphine, codeine, dihydrocodeine, fentanyl, heroin, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, propoxyphene, tapentadol, tramadol
1-25 ng/mL
amphetamine, cocaine, methamphetamine, MDMA (Ecstasy), MDEA (Eve), MDA, methylphenidate, phentermine
20-40 ng/mL
alprazolam, amobarbital, butalbital, chlordiazepoxide, clonazepam, diazepam, flurazepam, flunitrazepam, lorazepam, midazolam, nordiazepam, oxazepam, pentobarbital, phenobarbital, secobarbital, temazepam, triazolam, zolpidem
25-500 ng/mL
Cannabinoids (11-nor-9-carboxy-THC)60 ng/mL
Phencyclidine (PCP)10 ng/mL

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
80304 x2 (Alt code: G0479)
Component Test Code*Component Chart NameLOINC
2003257Buprenorphine (cutoff 5 ng/mL)
2003258Opioids, Serum or Plasma
2003280Stimulants, Serum or Plasma
2003281Sedative-Hypnotics, Serum or Plasma
2003282Cannabinoids, Serum or Plasma8171-1
2003283Phencyclidine, Serum or Plasma8235-4
2003600Norbuprenorphine (cutoff 10 ng/mL)66131-4
2003601Buprenorphine-G (cutoff 20 ng/mL)
2003602Norbuprenorphine-G (cutoff 20 ng/mL)
2003603Codeine (cutoff 10 ng/mL)16644-7
2003604Morphine (cutoff 10 ng/mL)17290-8
2003605Hydrocodone (cutoff 10 ng/mL)3679-8
2003607Hydromorphone (cutoff 10 ng/mL)3682-2
2003608Oxycodone (cutoff 10 ng/mL)13576-4
2003609Oxymorphone (cutoff 10 ng/mL)12342-2
20036106-Acetylmorphine (cutoff 10 ng/mL)43184-1
2003611Fentanyl (cutoff 1 ng/mL)29356-3
2003612Norfentanyl (cutoff 1 ng/mL)61052-7
2003613Meperidine (cutoff 5 ng/mL)3744-0
2003614Normeperidine (cutoff 5 ng/mL)10544-5
2003615Methadone (cutoff 25 ng/mL)3771-3
2003616EDDP (cutoff 25 ng/mL)41860-8
2003617Propoxyphene (cutoff 25 ng/mL)3542-8
2003619Tapentadol (cutoff 5 ng/mL)
2003620Tramadol (cutoff 5 ng/mL)
2003621N-Desmethyltramadol (cutoff 5 ng/mL)
2003622O-Desmethyltramadol (cutoff 5 ng/mL)
2003623Amphetamine (cutoff 20 ng/mL)66127-2
2003624Methamphetamine (cutoff 20 ng/mL)3777-0
2003625MDMA-Ecstasy (cutoff 20 ng/mL)40493-9
2003626MDA (cutoff 40 ng/mL)61045-1
2003627MDEA-Eve (cutoff 20 ng/mL)61047-7
2003628Cocaine (cutoff 20 ng/mL)8190-1
2003629Benzoylecgonine (cutoff 20 ng/mL)16446-7
2003630m-OH-Benzoylecgonine (cutoff 20 ng/mL)
2003631Cocaethylene (cutoff 20 ng/mL)13553-3
2003632Butalbital (cutoff 75 ng/mL)3420-7
2003633Phenobarbital (cutoff 500 ng/mL)3947-9
2003634Pentobarbital (cutoff 75 ng/mL)3923-0
2003635Amobarbital (cutoff 75 ng/mL)3337-3
2003636Secobarbital (cutoff 75 ng/mL)4027-9
2003637Nordiazepam (cutoff 25 ng/mL)13572-3
2003638Oxazepam (cutoff 25 ng/mL)12362-0
2003639Temazepam (cutoff 25 ng/mL)13580-6
2003640Diazepam (cutoff 25 ng/mL)3549-3
2003641Lorazepam (cutoff 25 ng/mL)13565-7
2003642Alprazolam (cutoff 25 ng/mL)13545-9
2003647Midazolam (cutoff 25 ng/mL)
2003648Clonazepam (cutoff 25 ng/mL)13550-9
20036497-Aminoclonazepam (cutoff 25 ng/mL)61029-5
20036509-Carboxy-THC (cutoff 60 ng/mL)26743-5
2003651PCP (cutoff 10 ng/mL)8235-4
2003705Drug Screen Comments54247-2
2007586Naloxone (cutoff 20 ng/mL)
2007587Naltrexone (cutoff 20 ng/mL)
2007588Methylphenidate (cutoff 20 ng/mL)3806-7
2007589Ritalinic Acid (cutoff 20 ng/mL)61059-2
2007590Phentermine (cutoff 20 ng/mL)
2007591Chlordiazepoxide (cutoff 25 ng/mL)3456-1
2007598Zolpidem (cutoff 25 ng/mL)6953-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Pain Management (Drug Screen, Targeted, Serum or Plasma)