Antiphospholipid Syndrome Reflexive Panel
Ordering Recommendation

Preferred initial panel when antiphospholipid syndrome (APS) is strongly suspected.

Electromagnetic Mechanical Clot Detection/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Light Blue (Sodium Citrate) AND Serum Separator Tube (SST). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines. 
Specimen Preparation
Transport 2 mL platelet poor plasma in an ARUP Standard Transport Tube. (Min: 2 mL)
Transport 1 mL serum in an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Plasma: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum: Refrigerated. 
Unacceptable Conditions
For Lupus Anticoagulant Reflexive Panel (Plasma): Serum. EDTA plasma, clotted or hemolyzed specimens.
For cardiolipin and beta-2 glycoprotein antibodies (Serum):
Plasma and other body fluids, heat-inactivated, hemolyzed, lipemic, or contaminated specimens. 
Plasma: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C or below: 3 months; Frozen at -70°C or below: 18 months
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Available Separately
Reference Interval
NoBeta-2 Glycoprotein 1 Antibody, IgGEffective February 18, 2014
0-20 SGU
NoBeta-2 Glycoprotein 1 Antibody, IgMEffective February 18, 2014
0-20 SMU
Yes (0050901)Cardiolipin Antibody, IgGEffective August 18, 2014
0-14 GPL: Negative
15-19 GPL: Indeterminate
20-80 GPL: Low to Moderately Positive
81 GPL or above: High Positive
Yes (0050902)Cardiolipin Antibody, IgMEffective August 18, 2014
0-12 MPL: Negative
13-19 MPL: Indeterminate
20-80 MPL: Low to Moderately Positive
81 MPL or above: High Positive
Yes (0030215)Prothrombin TimeEffective February 18, 2014
12.0-15.5 seconds
Yes (0030235)Partial Thromboplastin TimeEffective February 18, 2014
32-48 seconds
NoDilute Russell Viper Venom Time (dRVVT)Effective February 18, 2014
33-44 seconds
NoThrombin TimeEffective February 18, 2014
14.7-19.5 seconds
NoReptilase TimeEffective February 18, 2014
Less than 22.0 seconds
NoPTT Heparin NeutralizedEffective February 18, 2014
32-48 seconds
NoPartial Thromboplastin Time 1:1 Mix (performed if PTT >48 seconds)Effective February 18, 2014
32-48 seconds
NoPlatelet Neutralization Procedure (performed if PTT 1:1 Mix >48 seconds)Effective February 18, 2014
NoDilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT >44 seconds)Effective February 18, 2014
33-44 seconds
NoDilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix >44 seconds)Effective February 18, 2014
NoHexagonal Phospholipid NeutralizationEffective February 18, 2014

Interpretive Data
See individual components.

If PTT and dRVVT are normal, then no further testing is performed. If PTT is abnormal, Thrombin Time is added. If Thrombin Time is normal, PTT 1:1 mix is added. If Thrombin time is abnormal, Reptilase Time and PTT Heparin Neutralization are added. If PTT Heparin Neutralization is abnormal, PTT 1:1 mix is added. If PTT 1:1 mix is abnormal, Platelet Neutralization procedure is added. If dRVVT is abnormal, dRVVT 1:1 mix is added. If dRVVT 1:1 mix is abnormal, dRVVT confirmation is added. If Platelet Neutralization procedure and dRVVT confirmation are normal or if one is normal and the other not done, Hexagonal Phospholipid Neutralization is added. Additional charges apply.
Hotline History
CPT Code(s)
86147 x2; 86146 x2; 85610; 85730; 85613; if reflexed, additional CPT codes may apply: 85670; 85635; 85730; 85525; 85732; 85597; 85613 x2; 85598.
Component Test Code*Component Chart NameLOINC
0030079Lupus Anticoagulant Interpretation75882-1
0030082Hexagonal Phospholipid Neutral Reflex33930-9
0030084PTT-D Heparin Neutralized52123-7
0030184Platelet Neutralization (PTT-D, Confirm)15191-0
0030189dRVVT Confirmation50410-0
0030232PTT-LA Screen (PTT-D)34571-0
0030246Prothrombin Time5902-2
0030270Thrombin Time3243-3
0030296Reptilase Time6683-7
0030323PTT-D 1:1 Mix5946-9
0030352dRVVT Screen6303-2
0030353dRVVT 1:1 Mix75513-2
0050322B2Glycoprotein 1, IgG Antibody44448-9
0050323B2Glycoprotein 1, IgM Antibody44449-7
0050901Cardiolipin Antibody IgG3181-5
0050902Cardiolipin Antibody IgM3182-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ACA
  • aCL antibody
  • Anti-Phospholipid Syndrome Reflexive Panel (Antiphospholipid Syndrome Reflexive Panel)
  • APS panel
  • APS Reflexive Panel
  • B2Glycoprotein I
  • B2GPI
  • Cardiolipin Antibody
  • dRVVT Screen
  • Hexagonal Phospholipid Neutral Reflex
  • Hughes Syndrome Panel
  • Hypercoag
  • Hypercoagulable
  • Lupus Anticoagulant (LA)
  • Platelet Neutralization
  • Prothrombin Time
  • PTT-D Heparin Neutralized
  • Reptilase Time
  • Thrombin Time