Lacosamide, Serum or Plasma
Ordering Recommendation
Therapeutic drug monitoring.
High Performance Liquid Chromatography/Tandem Mass Spectrometry
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.  
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated: Also acceptable: Room temperature or frozen.  
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
Ambient: 15 days; Refrigerated: 15 days; Frozen: 15 days  
Reference Interval
Effective February 19, 2013
Reference Interval:
Therapeutic Range: Not well established. Suggested range 5.0-​10.0 µg/mL
Dose-​related range (values at doses of 200-​600 mg/day): 2.5-​18.0 µg/mL
Toxic Level Not well established.
Interpretive Data
Adverse effects may include dizziness, fatigue, nausea, vomiting, blurred vision and tremor.

See Compliance Statement B:
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
80339; (Alt code 80299)
Component Test Code*Component Chart NameLOINC
2003183Lacosamide, Serum or Plasma59297-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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