Tapentadol and Metabolite - Confirmation/Quantitation - Serum or Plasma
2003133
 
Ordering Recommendation
Mnemonic
TAPENTA SP
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu
Reported
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles.  
Remarks
 
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years  
Reference Interval
Interpretive Data
Methodology: LC-MS/MS

Drugs Covered:
Tapentadol, tapentadol glucuronide, tapentadol-O-sulfate (qualitative only), and n-desmethyltapentadol (qualitative only).

Positive Cutoff:
Tapentadol 50 ng/mL
Tapentadol glucuronide 100 ng/mL Tapentadol-O-sulfate 100 ng/mL
N-desmethyltapentadol 100 ng/mL

For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug is not uncommon and is consistent with recent use.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.
Note
CPT Code(s)
83925
Components
Component Test Code*Component Chart Name
2003134Tapentadol, Serum or Plasma
2003135N-desmethyltapentadol, Serum or Plasma
2005880Tapentadol glucuronide, Serum or Plasma
2005885Tapentadol-O-sulfate, Serum or Plasma
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Nucynta
  • nucynta blood level
  • Tapentadol blood level