MDM2 Gene Amplification by FISH
2003016
Ordering Recommendation
Aids in the differential diagnosis of lipomatous neoplasms. The presence of MDM2 amplification supports a diagnosis of well-differentiated liposarcoma / atypical lipomatous tumor, but it is not specific for these diagnoses.
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Mnemonic
MDM2 FISH
Methodology
Fluorescence in situ Hybridization
Performed
Varies
Reported
4-12 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Tumor tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 5 unstained 5 micron slides. (Min: 3 slides) Protect paraffin block from excessive heat. Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Frozen specimens. Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.  
Remarks
Include surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Refer to report.

See Compliance Statement A: www.aruplab.com/CS
Note
CPT Code(s)
88367
Components
Component Test Code*Component Chart Name
2003017MDM2 by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • MDM2 FISH
  • MDM2 Gene amplification