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Human Papillomavirus (HPV) Panel by in situ Hybridization, Paraffin (INACTIVE as of 11/18/13: Refer to 2002899 or 2002896)
2002893
Ordering Recommendation
Mnemonic
HPVPAN ISH
Methodology
In situ Hybridization
Performed
Mon-Fri
Reported
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Tissue. 
Specimen Preparation
Formalin fix (10% neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 10 unstained 5 micron slides in a tissue transport kit (ARUP supply #47808). Available online through eSupply using ARUP ConnectTM or contact ARUP Client Services at (800) 522-2787. (Min: 5 slides) Protect paraffin block and/or slides from excessive heat. 
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months. 
Unacceptable Conditions
Specimens fixed or processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). Frozen specimens. 
Remarks
Room temperature or refrigerated. Ship in cooled container during summer months. 
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Test Number
Components
Reference Interval
2002896Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin
2002899Human Papillomavirus (HPV), High Risk by in situ Hybridization, ParaffinNegative

Interpretive Data
This test detects: Low-risk HPV (genotypes: 6,11) and high-risk HPV (genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 66).

A negative result does not rule out the presence of an HPV genotype absent from the test panel, a low level infection, or specimen sampling error.

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

Note
CPT Code(s)
88365 x2
Components
Component Test Code*Component Chart NameLOINC
2002892HPV Panel ISH Comment48767-8
2002999ISH Tissue Source31208-2
2003000ISH Reference Number30896-5
2003001H and E Slide Description19772-3
2003006HPV ISH High Risk49896-4
2003008HPV ISH Low Risk17412-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HPV
  • HPV LR and HR ISH
  • HPV Panel ISH
  • HPVPAN ISH
  • Low risk and high risk HPV ISH
  • LR and HR HPV ISH