Factor XIII, Qualitative, with Reflex to Factor XIII 1:1 Mix
2002819
 
Ordering Recommendation
Most useful for acquired or severe FXIII deficiency testing. Abnormal results should be confirmed with quantitative testing (Factor XIII Activity 2006182)
Mnemonic
FACTOR 13
Methodology
Qualitative Solubility
Performed
Sun-Sat
Reported
2-3 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Non-frozen or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: 8 hours; Frozen: 2 weeks  
Reference Interval
Test Number Components Reference Interval
Factor XIII, Qualitative No Lysis within 24 hours
Factor XIII, 1:1 Mix Not Applicable
Interpretive Data
Note
This is a qualitative screening test; clot lysis only occurs in specimens with severe factor XIII deficiency (less than 1 percent of normal activity). Severe deficiency may be inherited or acquired (typically due to a factor XIII antibody). If clot lysis occurs in the initial testing, then Factor XIII 1:1 Mix will be added where the test is repeated using a 1:1 mix of patient plasma and pooled normal plasma to distinguish between FXIII deficiency and a FXIII inhibitor. Additional charges apply.

False-positive results (lysis) can be caused by heparin (therapy with unfractionated or low molecular weight heparin or contamination from a line), decreased or abnormal fibrinogen, increased fibrinolysis (inherited or acquired fibrinolytic disorders), fibrinolytic drugs, or other factors that affect clot structure or stability.
CPT Code(s)
85291; if reflexed, add additional 85291
Components
Component Test Code*Component Chart Name
2002818Factor XIII, 1:1 Mix
2002915Factor XIII, Qualitative
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Clot Solubility
  • Factor 13
  • Fibrin Stabilizing Factor