HLA-DQB Genotyping (INACTIVE as of 02/21/17: Refer to 2014079, 2014073 in the February Hotline)
Ordering Recommendation

Do not use for HLA-related disease screening or diagnosis (eg, celiac disease, narcolepsy, rheumatologic diseases). To rule out celiac disease (when other testing is inconclusive), refer to Celiac Disease (HLA-DQ2, and HLA-DQ8) Genotyping (2005018). When narcolepsy is suspected in symptomatic individuals, refer to Narcolepsy (HLA-DQB1*06:02) Genotyping (2005023).

Polymerase Chain Reaction/Sequence Specific Oligonucleotide Probe Hybridization
3-7 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA), pink (K2EDTA), or yellow (ACD Solution A or B). 
Specimen Preparation
Transport 5 mL whole blood. (Min: 3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Specimens collected in green (sodium or lithium heparin). 
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Background Information for HLA-DQB Genotyping:
For immunization/vaccination trials or to aid the clinical diagnosis of diseases strongly associated with the HLA-DQB locus.
Methodology: PCR followed by Sequence Specific Oligonucleotide Probe Hybridization of HLA-DQB locus.
Analytical Sensitivity & Specificity:
Medium to high resolution of HLA-DQB locus.
Limitations: The presence of a disease-associated HLA combination does not establish a diagnosis. If less than 2 alleles are reported for a locus, the patient is likely homozygous. Rare diagnostic errors can occur due to primer or probe site mutations. This test is not sufficient for comprehensive HLA evaluation for clinical hematopoietic stem cell transplantation (refer to HLA Class I (ABC) by Next Generation Sequencing-2011264 and/or HLA Class II (DRB1 and DQB1) by Next Generation Sequencing-2011272 ).

Counseling and informed consent are recommended for genetic testing. Consent forms are available online at

Order this test for single antigen HLA-DQB identification. Please specify antigens. Refer to HLA-DR Genotyping for single antigen HLA-DR identification.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2002811HLA Class II, Locus DQB*, Allele 143291-4
2002812HLA Class II, Locus DQB*, Allele 243291-4
2002813HLA-DQB Genotyping Interpretation53938-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Performed at UUHC - H&I Lab