Meperidine and Metabolite, Serum or Plasma, Quantitative (INACTIVE as of 2/20/18)
Ordering Recommendation

Monitor patient adherence.

Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Tue, Thu
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles. 
Submit With Order
1.  Dose - List drug amount of drug and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency -  Indicate  how often the dose is administered (per day, per week or as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.) 
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years 
Reference Interval
Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Meperidine2 ng/mL
Normeperidine (meperidine metabolite)5 ng/mL

Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive cutoff
Meperidine: 2 ng/mL
Normeperidine: 5 ng/mL

For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug may indicate use of parent drug during the prior week.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2002757Normeperidine, S/P, Quant10996-7
2002758Meperidine, S/P, Quant3745-7
2011511Meperidine Dose
2011512Meperidine Dose Frequency
2011513Meperidine Route
2011514Meperidine Type of Draw
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Centralgin
  • Demerol
  • Dispadol
  • Dolantin
  • Dolosal
  • Dolsin
  • Isonipecaine
  • Lidol
  • Mepergan
  • Meperidine (Meperidine & Metabolite - Confirmation/Quantitation - Serum or Plasma)
  • meperidine blood concentration
  • meperidine blood level
  • Normeperidine
  • Pethanol
  • Pethidine