Cryoglobulin, Qualitative with Reflex to IFE Typing and Quantitative IgA, IgG, and IgM
Ordering Recommendation

Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.

Qualitative Cold Precipitation/Qualitative Immunofixation Electrophoresis/Quantitative Nephelometry
3-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Fasting specimen required. 
Whole blood drawn in a pre-warmed (37°C) syringe. Specimen may be drawn directly into a pre-warmed plain red. 
Specimen Preparation
Maintain whole blood at 37°C until clotting is complete; do not refrigerate or freeze at any time. Immediately after blood has been obtained, transfer specimen to a pre-warmed plain red (if not used for collection). Separate serum from cells using a 37°C centrifuge, if possible. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. 
Unacceptable Conditions
Plasma. Serum separator tubes. Grossly hemolyzed or lipemic specimens. 
Proper collection and transport of specimen is critical to the outcome of the test. Quantities less than 3 mL may affect the sensitivity of the test. 
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
Effective November 16, 2015
Test NumberComponents
Reference Interval
0050185Cryoglobulin, QualitativeNegative at 72 hours.
2012572Immunofixation Electrophoresis, Qualitative, GelNormal IFE
Immunoglobulin A, Cryoprecipitate0 mg/dL
Immunoglobulin G, Cryoprecipitate0 mg/dL
Immunoglobulin M, Cryoprecipitate0 mg/dL

Interpretive Data

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. Additional charges apply.
Hotline History
View Hotline History
CPT Code(s)
82595; if reflexed, add 82784 x3; 86334
Component Test Code*Component Chart NameLOINC
0050185Cryoglobulin, Qualitative5117-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Cryoglobulins reflex test to IFE
  • Cryoglobulins/cryoglobulins
  • Cryoprotein
  • Quantitative cryoglobulins