Cryoglobulin, Qualitative with Reflex to IFE Typing and Quantitative IgA, IgG, and IgM
Ordering Recommendation
Qualitative Cold Precipitation/Qualitative Immunofixation Electrophoresis/Quantitative Nephelometry
3-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Fasting specimen required.  
Whole blood drawn in a pre-warmed (37°C) syringe. Specimen may be drawn directly into a pre-warmed plain red.  
Specimen Preparation
Maintain whole blood at 37°C until clotting is complete; do not refrigerate or freeze at any time. Immediately after blood has been obtained, transfer specimen to a pre-warmed plain red (if not used for collection). Separate serum from cells using a 37°C centrifuge, if possible. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL)  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.  
Unacceptable Conditions
Plasma. Serum separator tubes. Grossly hemolyzed or lipemic specimens.  
Proper collection and transport of specimen is critical to the outcome of the test. Quantities less than 3 mL may affect the sensitivity of the test.  
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
Available Separately Components Reference Interval
0050185Cryoglobulin, Qualitative Negative at 72 hours.
0050272Immunofixation Electrophoresis Gel (INACTIVE as of 01/04/16: Refer to November 2015 Hot Line for Replacement Test: 2012572, ACTIVE 11/16/15) Normal IFE
 Immunoglobulin A, Cryoprecipitate 0 mg/dL
 Immunoglobulin G, Cryoprecipitate 0 mg/dL
 Immunoglobulin M, Cryoprecipitate 0 mg/dL
Interpretive Data

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. Additional charges apply.
CPT Code(s)
82595; if reflexed, add 86334 and 82784 x3
Component Test Code*Component Chart NameLOINC
0050185Cryoglobulin, Qualitative5117-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Cryocrit
  • Cryoglobulins reflex test to IFE
  • Cryoglobulins/cryoglobulins
  • Cryoprotein
  • Quantitative cryoglobulins