Myeloproliferative Disorders Panel by FISH
2002360
Ordering Recommendation
Limited role in the work-up of myeloproliferative neoplasms in the setting of an otherwise optimal cytogenetic study.  Aids in exclusion of cryptic BCR-ABL1 rearrangement in chronic myelogenous leukemia and in the exclusion of a PDGFRA abnormality in cases of neoplastic eosinophilia. 
Mnemonic
FISH MPD P
Methodology
Fluorescence in situ Hybridization
Performed
Sun-Sat
Reported
3-10 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive

Additional Technical InformationAdditional Technical Information

Oncology Test Request Form Recommended (ARUP form #43099)Oncology Test Request Form Recommended (ARUP form #43099)

Specimen Required
Patient Preparation
  
Collect
Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).  
Specimen Preparation
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.  
Remarks
  
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Probes included: BCR/ABL, PDGFR-alpha, PDGFR-beta, and, FGFR1.

See Compliance Statement A: www.aruplab.com/CS
Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
 
Note
A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.

Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
CPT Code(s)
88271 x4; 88275 x4; 88291
Components
Component Test Code*Component Chart NameLOINC
2002361MPD Panel by FISH 
2002362EER FISH MPD P 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases