Chromosome FISH, Metaphase
2002299
Ordering Recommendation
 
Mnemonic
CHR FISHM
Methodology
Fluorescence in situ Hybridization
Performed
Sun-Sat
Reported
3-10 days  
New York DOH Approval Status
This test is New York DOH approved.
Time SensitiveTime Sensitive

Cytogenetic Test Request Form Recommended (ARUP form #43097)Cytogenetic Test Request Form Recommended (ARUP form #43097)

Specimen Required
Patient Preparation
  
Collect
Green (sodium heparin). Also acceptable: Non-diluted bone marrow aspirate collected in a heparinized syringe.  
Specimen Preparation
Transport 5 mL whole blood (Min: 2 mL). OR transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL).  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.  
Remarks
If FISH only is requested, please submit a copy of previous cytogenetics report.
Submit the Patient History for Cytogenetic (Chromosome) Studies form with the electronic packing list (available at http://www.aruplab.com/genetics/forms.php).  
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

See Compliance Statement A: www.aruplab.com/CS
Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
 
Note
Time required for culture as well as testing can vary depending on specimen type and probes ordered.
Please indicate names of probes requested. Molecular Cytogenetics (FISH) Probe menu is available at http://www.aruplab.com/Lab-Tests/Genetics/cytogenetics.jsp 
Contact ARUP Genetics Processing at extension 3301 to add a probe to a current specimen.
A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.

It is recommended that all FISH studies be done in conjunction with routine cytogenetic analysis. (Refer to appropriate Chromosome Analysis test for order instructions).

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.
This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface.
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.
CPT Code(s)
88271; 88273; 88291
Components
Component Test Code*Component Chart NameLOINC
0097615Chromosome FISH, Metaphase21717-4
2002202EER Chromosome FISH, Metaphase11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 15q11.2-13 duplication (15q11.2-13)
  • Angelman syndrome (15q11.2-13)
  • Cri-du-chat (5p-) syndrome (5p15.2)
  • DiGeorge/Velocardiofacial (VCF) syndrome (22q11.2)
  • Kallmann syndrome (Xp22.3)
  • Miller-Dieker (Lissencephaly) syndrome (17p13.3)
  • Phelan-McDermid (22qter) syndrome (22q13.3)
  • Prader-Willi syndrome (15q11.2-13)
  • SHOX (Xp22.3)
  • Smith-Magenis syndrome (17p11.2)
  • SRY/male detection (Yp11.3)
  • Steroid sulfatase deficiency (STS) (Xp22.3)
  • Williams (elastin) syndrome (7q11.23)
  • Wolf-Hirschhorn (4p-) syndrome (4p16.3)
  • Yq12