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Time Sensitive

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Oncology Test Request Form Recommended (ARUP form #43099)

Ordering Recommendation

Use to order individual or multiple oncology FISH probes if standard FISH panels are not desired.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Paraffin-embedded specimens. Clotted specimens.

Remarks

Desired FISH probe and pertinent clinical diagnosis required with test order. Testing will not be performed until probe and diagnosis are provided; absence of this information will delay turnaround time.

Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Sun-Sat

Reported

3-10 days

Reference Interval

By report

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Time required for testing can vary depending on specimen type and probes ordered.

Please indicate the names of probes needed for testing. Molecular Cytogenetics (FISH) Probe menu is available at https://www.aruplab.com/Testing-Information/resources/FISH_probes/fish_probes_oncology.pdf
Contact ARUP Genetics Processing at extension 3301 to add a probe to a current specimen.

Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Hotline History

N/A

CPT Codes

88271; 88275

Components

Component Test Code* Component Chart Name LOINC
0092615 Chromosome FISH, Interphase 57802-1
2002196 EER Chromosome FISH, Interphase 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • +10
  • +12
  • +15
  • +17
  • +4
  • +8
  • +9
  • 11q23
  • 12q31
  • 13q13
  • 14q32
  • 18q11.2
  • 18q21
  • 19p13
  • 1q21
  • 20q Deletion (D20S108)
  • 21q22
  • 22q12.2
  • 3q27
  • 4q12
  • 5q Deletion (EGR1)/Monosomy 5
  • 5q32
  • 5q33.1
  • 7q Deletion(D7S486)/Monosomy 7
  • 8p12
  • 8q24
  • 9p21
  • ABL1 Rearrangement
  • ABL2 Rearrangement
  • ATM Deletion
  • BCL6 Rearrangement
  • BCR-ABL1
  • C-Myc (MYC) Rearrangement
  • Cancer FISH
  • CBFB Rearrangement
  • CBFB-MYH11 Fusion, t(16;16)(p13.1;q22)
  • CKS1B
  • CRLF2 Rearrangement
  • CSF1R Rearrangement
  • D13S319 Deletion
  • DDIT3 (CHOP)
  • del(11)(q22.3)
  • del(13)(q14.3)
  • del(17)(p13.1) (TP53) Deletion
  • del(20)(q12)
  • del(5)(q31)/-5
  • del(7)(q31)/-7
  • EGR1
  • EPOR Rearrangement
  • ETV6 Rearrangement
  • ETV6-RUNX1 (TEL-AML1 ) Fusion
  • EWSR1 Rearrangement
  • FGFR1 Rearrangement
  • FGFR1, 8p11-12
  • FKHR (FOXO1)
  • Hyperdiploidy with Trisomy 4, 10, and 17
  • IGH Rearrangement
  • IGH-BCL2 Fusion
  • IGH-CCND1 Fusion
  • IGH-FGFR3 Fusion
  • IGH-MAF Fusion
  • IGH-MAFB Fusion
  • IKZF1 (Ikaros) Deletion
  • inv(16)
  • inv(16)(p13.3q22)
  • inv(3)
  • JAK2 Rearrangement
  • KMT2A (MLL) Rearrangement
  • MALT1
  • NUP98 Rearrangement
  • oncology FISH
  • p16 (CDKN2) Deletion
  • PDGFR-alpha Rearrangement
  • PDGFR-beta Rearrangement
  • PDGFRA Rearrangement
  • PDGFRA-CHIC2-FIP1L1
  • PDGFRB Rearrangement
  • PDGFRB, 5q33.1
  • Philadelphia chromosome
  • PML-RARA Fusion
  • RPN1/MECOM (EVI1)
  • RUNX1 Rearrangement
  • RUNX1T1-RUNX1 (ETO-AML1) Fusion
  • SS18 (SYT) Rearrangement
  • t(11;14)(q13;q32)
  • t(12;21)(p13;q22)
  • t(14;16)(q32;q23.1)
  • t(14;18)(q32;q21)
  • t(14;20)(q32;q12)
  • t(15;17)(q24;q21)
  • t(3:3)
  • t(4;14)(p16;q32)
  • t(8;21)(q22;q22)
  • t(9;22)(q34;q11.2)
  • TCF3 (E2A) Rearrangement
  • TCL1 Rearrangement
  • TP53 (p53) Deletion
  • Trisomy 10
  • Trisomy 12
  • Trisomy 15
  • Trisomy 17
  • Trisomy 4
  • Trisomy 8
  • Trisomy 9
  • X and Y centromere (CEP X/Y)
Chromosome FISH, Interphase