Chromosome FISH, Prenatal
2002297
Ordering Recommendation
Rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. Assay  offered in conjunction with chromosome study.
Mnemonic
CHR FISHP
Methodology
Fluorescence in situ Hybridization
Performed
Sun-Sat
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Time SensitiveTime Sensitive

Cytogenetic Test Request Form Recommended (ARUP form #43097)Cytogenetic Test Request Form Recommended (ARUP form #43097)

Specimen Required
Patient Preparation
  
Collect
Amniotic fluid.  
Specimen Preparation
Do not freeze or expose to extreme temperatures. Transport 30 mL amniotic fluid in sterile centrifuge tubes. (Min: 15 mL)  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Bloody specimens.  
Remarks
  
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com  
Note
Fluorescence in situ hybridization (FISH) is performed for aneuploidy of chromosomes X, Y, 13, 18, and 21.

The FISH analysis does not detect structural chromosome abnormalities, mosaicism, and other numerical chromosome abnormalities (excluding X, Y, 13, 18, and 21). In addition, false-positive or negative results, as well as maternal cell contamination, have been demonstrated in prenatal FISH analysis. The American College of Medical Genetics recommends that irreversible therapeutic action should not be initiated on the basis of FISH results alone.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow culture growth.

It is recommended that FISH be performed in conjunction with routine cytogenetic analysis.

Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection.
This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Submit the Patient History for Cytogenetic (Chromosome) Studies form with the electronic packing list (available at available at http://www.aruplab.com/genetics/forms.php).
CPT Code(s)
88271 x5; 88275 x5; 88291
Components
Component Test Code*Component Chart NameLOINC
0097779Chromosome FISH, Prenatal55192-9
2002211EER Chromosome FISH, Prenatal 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AF, amniotic fluid, Insight, PN FISH
  • Common trisomy FISH panel
  • prenatal FISH