Rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. Assay offered in conjunction with chromosome study.
- Patient Preparation
- Amniotic fluid.
- Specimen Preparation
- Do not freeze or expose to extreme temperatures. Transport 30 mL amniotic fluid in sterile centrifuge tubes. (Min: 15 mL)
- Storage/Transport Temperature
- Room temperature.
- Unacceptable Conditions
- Frozen specimens. Bloody specimens.
- Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
The FISH analysis does not detect structural chromosome abnormalities, mosaicism, and other numerical chromosome abnormalities (excluding X, Y, 13, 18, and 21). In addition, false-positive or negative results, as well as maternal cell contamination, have been demonstrated in prenatal FISH analysis. The American College of Medical Genetics recommends that irreversible therapeutic action should not be initiated on the basis of FISH results alone.
A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow culture growth.
It is recommended that FISH be performed in conjunction with routine cytogenetic analysis.
Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection.
This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Submit the Patient History for Cytogenetic (Chromosome) Studies form with the electronic packing list (available at available at http://www.aruplab.com/genetics/forms.php).
|Component Test Code*||Component Chart Name||LOINC|
|0097779||Chromosome FISH, Prenatal||55192-9|
|2002211||EER Chromosome FISH, Prenatal|
- AF, amniotic fluid, Insight, PN FISH
- Common trisomy FISH panel
- prenatal FISH