Multiple Myeloma Panel by FISH
Time SensitiveTime Sensitive

Additional Technical InformationAdditional Technical Information

Oncology Test Request Form Recommended (ARUP form #43099)Oncology Test Request Form Recommended (ARUP form #43099)

Ordering Recommendation
Aids in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in low-risk individuals at time of relapse.
Submit With Order
Fluorescence in situ Hybridization
5-14 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).  
Specimen Preparation
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.  
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data

See Compliance Statement A:
Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities: CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion). If IGH is positive and not partnered with CCND1, additional testing will include FGFR3/IGH and MAF/IGH. Additional charges will apply.

This test must be ordered using Cytogenetic test request form 43097 or through your ARUP interface.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.
CPT Code(s)
88271 x6; 88275 x6; 88291
Component Test Code*Component Chart Name
0092617Multiple Myeloma Panel by FISH
2002198EER Multiple Myeloma Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References