Multiple Myeloma Panel by FISH
Ordering Recommendation

Aids in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in low-risk individuals at time of relapse.

Fluorescence in situ Hybridization
5-14 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive
Oncology Test Request Form Recommended (ARUP form #43099)Oncology Test Request Form Recommended (ARUP form #43099)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin). 
Specimen Preparation
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL). 
Storage/Transport Temperature
Room temperature. 
Unacceptable Conditions
Frozen specimens. Paraffin-embedded specimens. Clotted specimens. 
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities:  CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion).  If IGH is positive and not partnered with CCND1, additional testing will include FGFR3/IGH and MAF/IGH.  Additional charges will apply.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.
Hotline History
View Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0092617Multiple Myeloma Panel by FISH57802-1
2002198EER Multiple Myeloma Panel by FISH11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.