Prenatal chromosome analysis on chorionic villi when individual
• Is at increased risk for fetal aneuploidy based on maternal age, abnormal noninvasive prenatal testing (NIPT), abnormal multiple marker screening, or abnormal fetal ultrasound.
• Has a family history of chromosome abnormality or genetic disorder.
• Desires diagnostic testing instead of screening.
- Patient Preparation
- Thaw media prior to collection.
- Specimen Preparation
- DO NOT FREEZE. Do not place in formalin. Transport chorionic villus (CVS) specimen in a sterile, screw-top container filled with tissue culture transport medium.
- Storage/Transport Temperature
- Room temperature
- Unacceptable Conditions
- Frozen specimens. Specimens preserved in formalin.
- Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
A processing fee to cover sex confirmation and rule out maternal contamination by FISH is added to all Chromosome Analysis, Chorionic Villus Sampling (CVS) tests. An additional processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth.
Chorionic villus in a sterile, screw-top container filled with tissue culture transport medium (ARUP Supply #32788). Available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, saline, or ringers.
If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.
This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (available at http://www.aruplab.com/genetics/forms.php).
|Component Test Code*||Component Chart Name||LOINC|
|0097610||Chromosome Analysis, Chorionic Villus||33774-1|
|2002201||EER Chromosome Analysis Chorionic Villus|
- chorionic villi
- Karyotype, CVS
- NIPD confirmation study
- NIPT confirmation study
- Prenatal Chromosomes, CVS
- Prenatal Diagnosis, CVS, Chromosome Analysis