Chromosome Analysis, Products of Conception
2002288
Time SensitiveTime Sensitive

Cytogenetic Test Request Form Recommended (ARUP form #43097)Cytogenetic Test Request Form Recommended (ARUP form #43097)

Ordering Recommendation
Order for standard chromosome analysis performed on cultured fetal or placental cells.
Mnemonic
CHR POC
Methodology
Giemsa Band
Performed
Sun-Sat
Reported
Varies
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container (Wide mouth containers: ARUP supply #42710) filled with tissue culture transport medium (ARUP Supply # 32788). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers.
If autopsy is performed:
Facia lata, diaphragm, tendon, skin, tissue from internal organs (if fresh), chest wall cartilage (particularly if macerated) or placenta from fetal side.
If no autopsy is performed:
Placenta from fetal side is preferred (e.g. villi).
Also acceptable: Umbilical cord or achilles tendon.  
Specimen Preparation
DO NOT FREEZE. Do not place in formalin. Transport products of conception (Min: 5 mg) in sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.  
Storage/Transport Temperature
Room temperature (fresh tissue or culture flask). Also acceptable: Refrigerated.  
Unacceptable Conditions
Frozen specimens. Intact fetus. Specimens preserved in formalin. Specimens consisting of maternal tissue (decidua) only. Autolyzed or contaminated specimens.  
Remarks
If specimen collection time is greater than 72 hours, testing may be compromised. The laboratory will make every attempt to culture the specimen. Send specimen to lab for testing. This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Please submit the Patient History Form - Cytogenetics (Chromosome) Testing, Prenatal with the Electronic Packing List. The form is available on ARUP's Web site, http://www.aruplab.com/genetics/resources/patient-history.  
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
Interpretive Data
Refer to report.



Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

See Compliance Statement C: www.aruplab.com/CS
Note
These studies involve culturing of living cells; therefore, turnaround times given represent average times which are subject to multiple variables. After specimen receipt, results are generally available in an average of 14 days.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth.
CPT Code(s)
88262; 88233; 88291
Components
Component Test Code*Component Chart Name
0097645Chromosome Analysis, Prod Concp
2002206EER Chromosome Analysis, Prod Concp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Autopsy (ONLY if Chromosomes are indicated)
  • Chromosome Analysis, Stillbirth or Miscarriage
  • intrauterine fetal demise
  • IUFD
  • Karyotype
  • Karyotype, Stillbirth or Miscarriage
  • Miscarriage
  • missed abortion
  • Pregnancy loss
  • SAB
  • Spontaneous abortion
  • Stillbirth