Congenital Adrenal Hyperplasia Panel, 21-Hydroxylase Deficiency
2002283
Ordering Recommendation
 
Mnemonic
CAH 21 HYDROX
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Collect between 6-10 a.m.  
Collect
Serum separator tube or green (sodium or lithium heparin). Also acceptable: Pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1.8 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.9 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Refrigerated or room temperature specimens.  
Remarks
  
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 6 months  
Reference Interval
 
 
Available Separately Components Reference Interval
2001638Androstenedione Effective August 19, 2013
 
Age Female Male
Premature Infants, 26-​28 weeks-​Day 4 0.92-​2.82 ng/mL 0.92-​2.82 ng/mL
Premature Infants, 31-​35 weeks-​Day 4 0.80-​4.46 ng/mL 0.80-​4.46 ng/mL
Full-​term Infants, 1-​7 days 0.20-​2.90 ng/mL 0.20-​2.90 ng/mL
8-​30 days 0.18-​0.80 ng/mL 0.18-​0.80 ng/mL
1-​5 months 0.06-​0.68 ng/mL 0.06-​0.68 ng/mL
6-​24 months Less than 0.15 ng/mL 0.03-​0.15 ng/mL
2-​3 years Less than 0.16 ng/mL Less than 0.11 ng/mL
4-​5 years 0.02-​0.21 ng/mL 0.02-​0.17 ng/mL
6-​7 years 0.02-​0.28 ng/mL 0.01-​0.29 ng/mL
8-​9 years 0.04-​0.42 ng/mL 0.03-​0.30 ng/mL
10-​11 years 0.09-​1.23 ng/mL 0.07-​0.39 ng/mL
12-​13 years 0.24-​1.73 ng/mL 0.10-​0.64 ng/mL
14-​15 years 0.39-​2.00 ng/mL 0.18-​0.94 ng/mL
16-​17 years 0.35-​2.12 ng/mL 0.30-​1.13 ng/mL
18-​39 years 0.26-​2.14 ng/mL 0.33-​1.34 ng/mL
40 years and older 0.13-​0.82 ng/mL 0.23-​0.89 ng/mL
Pre-​menopausal 0.26-​2.14 ng/mL Does Not Apply
Postmenopausal 0.13-​0.82 ng/mL Does Not Apply
Tanner Stage I 0.05-​0.51 ng/mL 0.04-​0.32 ng/mL
Tanner Stage II 0.15-​1.37 ng/mL 0.08-​0.48 ng/mL
Tanner Stage III 0.37-​2.24 ng/mL 0.14-​0.87 ng/mL
Tanner Stage IV-​V 0.35-​2.05 ng/mL 0.27-​1.07 ng/mL
009233217-​Hydroxyprogesterone Quantitative by HPLC-​MS/MS, Serum or Plasma Effective August 19, 2013
 
Age Female Male
Premature (26-​28 weeks) 124-​841 ng/dL 124-​841 ng/dL
Premature (29-​35 weeks) 26-​568 ng/dL 26-​568 ng/dL
Full term Day 3 7-​77 ng/dL 7-​77 ng/dL
4 days-​30 days 7-​106 ng/dL Less than 200 ng/dL
1 month-​2 months 13-​106 ng/dL Less than 200 ng/dL
3 months-​5 months 13-​106 ng/dL 3-​90 ng/dL
6  months-​1 year Less than or equal to 148 ng/dL Less than or equal to 148 ng/dL
2-​3 years Less than or equal to 256 ng/dL Less than or equal to 228 ng/dL
4-​6 years Less than or equal to 299 ng/dL Less than or equal to 208 ng/dL
7-​9 years Less than or equal to 71 ng/dL Less than or equal to 63 ng/dL
10-​12 years Less than or equal to 129 ng/dL Less than or equal to 79 ng/dL
13-​15 years 9-​208 ng/dL 9-​140 ng/dL
16-​17 years Less than or equal to 178 ng/dL 24-​192 ng/dL
18 years and older Less than 207 ng/dL Less than 139 ng/dL
Follicular 15-​70 ng/dL Does Not Apply
Luteal 35-​290 ng/dL Does Not Apply
Tanner Stage I Less than or equal to 74 ng/dL Less than or equal to 62 ng/dL
Tanner Stage II Less than or equal to 164 ng/dL Less than or equal to 104 ng/dL
Tanner Stage III 13-​209 ng/dL Less than or equal to 151 ng/dL
Tanner Stage IV-​V 7-​170 ng/dL 20-​173 ng/dL
009233317-​Hydroxypregnenolone Quantitative by LC-​MS/MS, Serum or Plasma  
 
Age Female Male
Premature (26-​28 weeks) 1219-​9799 ng/dL 1219-​9799 ng/dL
Premature (29-​36 weeks) 346-​8911 ng/dL 346-​8911 ng/dL
Full Term (1-​5 months) 229-​3104 ng/dL 229-​3104 ng/dL
6-​12 months less than or equal to 917ng/dL less than or equal to 917ng/dL
13-​23 months less than or equal to 592 ng/dL less than or equal to 592 ng/dL
2-​4 years less than or equal to 280 ng/dL less than or equal to 249 ng/dL
5-​6 years less than or equal to 350 ng/dL less than or equal to 319 ng/dL
7-​9 years less than or equal to 212 ng/dL less than or equal to 187 ng/dL
10-​12 years less than or equal to 398 ng/dL less than or equal to 392 ng/dL
13-​15 years less than or equal to 407 ng/dL 35-​465 ng/dL
16-​17 years less than or equal to 423 ng/dL 32-​478 ng/dL
18 years and older Less than 226 ng/dL Less than 442 ng/dL
Tanner Stage I less than or equal to 235 ng/dL less than or equal to 208 ng/dL
Tanner Stage II less than or equal to 367 ng/dL less than or equal to 355 ng/dL
Tanner Stage III less than or equal to 430 ng/dL less than or equal to 450 ng/dL
Tanner Stage IV-​V less than or equal to 412 ng/dL 35-​478 ng/dL
2001640Dehydroepiandrosterone, Serum or Plasma Effective August 19, 2013
 
Age Female Male
Premature Less than 40 ng/mL Less than 40 ng/mL
0-​1 day Less than 11 ng/mL Less than 11 ng/mL
2-​6 days Less than 8.7 ng/mL Less than 8.7 ng/mL
7 days-​1 month Less than 5.8 ng/mL Less than 5.8 ng/mL
1-​5 months Less than 2.9 ng/mL Less than 2.9 ng/mL
6-​24 months Less than 1.9 9 ng/mL Less than 2.5 ng/mL
2-​3 years Less than 0.85 ng/mL Less than 0.63 ng/mL
4-​5 years Less than 1.03 ng/mL Less than 0.95 ng/mL
6-​7 years Less than 1.79 ng/mL 0.06-​1.93 ng/mL
8-​9 years 0.14-​2.35 ng/mL 0.10-​2.08 ng/mL
10-​11 years 0.43-​3.78 ng/mL 0.32-​3.08 ng/mL
12-​13 years 0.89-​6.21 ng/mL 0.57-​4.10 ng/mL
14-​15 years 1.22-​7.01 ng/mL 0.93-​6.04 ng/mL
16-​17 years 1.42-​9.00 ng/mL 1.17-​6.52 ng/mL
18-​39 years 1.33-​7.78 ng/mL 1.33-​7.78 ng/mL
40 years and older 0.63-​4.70 ng/mL 0.63-​4.70 ng/mL
Postmenopausal 0.60-​5.73 ng/mL Does Not Apply
Tanner Stage I 0.14-​2.76 ng/mL 0.11-​2.37 ng/mL
Tanner Stage II 0.83-​4.87 ng/mL 0.37-​3.66 ng/mL
Tanner Stage III 1.08-​7.56 ng/mL 0.75-​5.24 ng/mL
Tanner Stage IV-​V 1.24-​7.88 ng/mL 1.22-​6.73 ng/mL
Interpretive Data


See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
 
CPT Code(s)
82157; 83498; 84143; 82626
Components
Component Test Code*Component Chart Name
009233217-Hydroxyprogesterone, HPLC-MS/MS
009233317-Hydroxypregnenolone Quant, MS/MS, Ser
2001639Androstenedione by TMS
2001641Dehydroepiandrosterone by TMS
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 17-Hydroxypregnenolone (CAH 21 Hydroxylase Deficiency Panel)
  • 17-Hydroxyprogesterone (CAH 21 Hydroxylase Deficiency Panel)
  • Androstenedione (CAH 21 Hydroxylase Deficiency Panel)
  • Dehydroepiandrosterone (DHEA) (CAH 21 Hydroxylase Deficiency Panel)