ST2, Soluble
2002270
 
Ordering Recommendation
B-Type Natriuretic Peptide (0030191) or proBrain Natriuretic Peptide, NT (0050083) are preferred tests for diagnosis, prognosis, and management of acute and chronic heart failure. ST2 aids in prognostication in patients with acute and chronic heart failure.
Mnemonic
ST2
Methodology
Quantitative Enzyme Immunoassay
Performed
Tue
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube, plain red, lavender (EDTA) or pink (K2EDTA).  
Specimen Preparation
Allow serum specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transport 1 mL serum or plasma. (Min: 0.2 mL) Avoid repeated freeze/thaws.)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Specimen types other than serum or plasma. Specimens stored or transported at room temperature for more than 48 hours.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 10 days; Frozen: 1 year  
Reference Interval
Males 10.4-​52.1 ng/mL
Females 8.4-​33.6 ng/mL
Interpretive Data
The ST2 test, an enzyme-linked immunosorbent assay, quantifies soluble ST2 in serum or plasma. ST2 is a member of the interleukin-1 (IL-1) receptor family and is secreted by cardiac muscle cells under conditions of mechanical stress. In individuals with acute myocardial infarction, an increased concentration of soluble ST2 is associated with an increased risk of mortality or heart failure. In individuals with heart failure, an increased concentration of soluble ST2 is strongly associated with the severity of disease and is a strong predictive indicator of 1-year mortality that is independent but additive to that of NT-proBNP.
Note
CPT Code(s)
83520
Components
Component Test Code*Component Chart Name
2002268ST2, Soluble
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • ST2