ST2, Soluble
Ordering Recommendation
B-Type Natriuretic Peptide (0030191) or proBrain Natriuretic Peptide, NT (0050083) are preferred tests for diagnosis, prognosis, and management of acute and chronic heart failure. ST2 aids in prognostication in patients with acute and chronic heart failure.
Quantitative Enzyme Immunoassay
Tue, Fri
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube, plain red, lavender (EDTA), pink (K2EDTA), or Green (Sodium or Lithium Heparin).  
Specimen Preparation
Allow serum specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transport 1 mL serum or plasma. (Min: 0.2 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Citrated plasma  
After separation from cells: Ambient: 48 hours; Refrigerated: 10 days; Frozen: 18 months  
Reference Interval
Males 10.4-​52.1 ng/mL
Females 8.4-​33.6 ng/mL
Interpretive Data
The Presage ST2 test, an enzyme-linked immunosorbent assay, quantifies soluble ST2 in serum or plasma. ST2 is a member of the interleukin-1 (IL-1) receptor family and is secreted by cardiac muscle cells under conditions of mechanical stress. In individuals with acute myocardial infarction, an increased concentration of soluble ST2 is associated with an increased risk of mortality or heart failure. In individuals with heart failure, an increased concentration of soluble ST2 is strongly associated with the severity of disease and is a strong predictive indicator of 1-year mortality that is independent but additive to that of NT-proBNP.  
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2002268ST2, Soluble55927-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ST2