Protein S, Free Antigen with Reflex to Protein S, Total Antigen
2002269
Ordering Recommendation
Use to detect and subtype protein S deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
PRS FREE R
Methodology
Microlatex Particle-Mediated Immunoassay
Performed
Mon-Fri
Reported
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6-9 years: 62-130%
10-17 years: 60-140%
18 years and older Male: 74-147%
18 years and older Female: 55-123%  
Interpretive Data
Patients on warfarin may have decreased free protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of free protein S levels. Decreased levels of free protein S are also associated with DIC, liver disease, pregnancy, and inflammatory syndromes.  
Note
If low Protein S Free Antigen is detected, then Protein S, Total Antigen, will be added. Additional charges apply.
CPT Code(s)
85306; if reflexed, add: 85305
Components
Component Test Code*Component Chart NameLOINC
0098894Protein S Ag Free27821-8
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Aliases
  • Protein S Profile
  • Protein S, Free and Total Antigen