Osmotic Fragility, Erythrocyte
2002257
Ordering Recommendation
 
Mnemonic
OSM FRG
Methodology
Spectrophotometry
Performed
Mon-Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive

Specimen Required
Patient Preparation
  
Collect
Green (sodium or lithium heparin) or Lavender (EDTA).  
Specimen Preparation
Transport 2 unfixed, air-dried, and unstained smears to accompany the collected blood (smears should be made from the blood submitted) (Min: 2 smears). AND 5 mL whole blood (Min: 1 mL). Specimens should be refrigerated within 30 minutes after collection..  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Grossly hemolyzed specimens.  
Remarks
  
Stability
Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: Unacceptable  
Reference Interval
Within normal curve limits. A graph will accompany laboratory report.  
Interpretive Data
For patients with acute hemolysis, a normal red cell osmotic fragility test result cannot exclude an osmotic fragility abnormality since the osmotically labile cells may be hemolyzed and not present. Recommend testing during a state of prolonged homeostasis with stable hematocrit.  
Note
 
CPT Code(s)
85555
Components
Component Test Code*Component Chart Name
0049015Osmotic Fragility
2002142EER Osmotic Fragility
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Aliases
  • FRAGILITY, OSMOTIC (RBC)
  • Osmotic Fragility
  • RBC Fragility, Erythrocytes
  • Red Cell Fragility
  • Spherocytic Hemolytic Disease