Porphyrins and Porphobilinogen (PBG), Urine
Ordering Recommendation

Evaluate patients with suspected porphyria presenting with neurologic/psychiatric, abdominal, and/or cutaneous symptoms.

High Performance Liquid Chromatography/Ion Exchange Chromatography/Quantitative Spectrophotometry
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
24-hour or random urine. Refrigerate 24-hour specimens during collection. 
Specimen Preparation
Protect from light. Transfer 8 mL aliquot to an ARUP Amber Transport Tube. (Min: 4 mL) Record total volume and collection time interval on transport tube and test request form. 
Storage/Transport Temperature
Unacceptable Conditions
Body fluids other than urine. 
Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month 
Reference Interval
Test Number
Reference Interval
Uroporphyrin0-4 µmol/mol crt
Heptacarboxylate Porphyrin0-2 µmol/mol crt
Coproporphyrin I0-6 µmol/mol crt
Coproporphyrin III0-14 µmol/mol crt
Porphobilinogen, Urine0.0-8.8 µmol/L
Porphobilinogen, Urine (24-hour)0.0-11.0 µmol/d
0020473Creatinine, 24-Hour Urine
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d

Interpretive Data
Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine).

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Urine porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittent porphyria (AIP).
CPT Code(s)
84120; 84110
Component Test Code*Component Chart NameLOINC
0020207Creatinine, Urine - per volume2161-8
0020208Creatinine, Urine - per 24h2162-6
0080262Porphobilinogen (PBG), Urine -per volume2811-8
0080365Uroporphyrin - ratio to CRT32043-2
0080366Heptacarboxylate - ratio to CRT38175-6
0080369Porphobilinogen (PBG), Urine -per 24h14882-5
0080459Porphyrin Urine Interpretation49292-6
0097110Total Volume19153-6
0097111Hours Collected30211-7
2002059Coproporphyrin I - ratio to CRT45313-4
2002061Coproporphyrin III - ratio to CRT45315-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Coproporphyrin
  • Heptacarboxyl Porphyrin
  • Hexacarboxyl Porphyrin
  • PBG
  • Pentacarboxyl Porphyrin
  • Porphobilinogen
  • Porphyrins, Quantitative, 24-Hour Urine
  • Urine Quantitative
  • Uroporphyrin