Porphyrins and Porphobilinogen (PBG), Urine
2002181
 
Ordering Recommendation
Mnemonic
PORUFPBGU
Methodology
High Performance Liquid Chromatography/Ion Exchange Chromatography/Quantitative Spectrophotometry
Performed
Mon-Fri
Reported
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
24-hour or random urine. Refrigerate 24-hour specimens during collection.  
Specimen Preparation
Protect from light. Transfer 8 mL aliquot to an ARUP Amber Transport Tube. (Min: 4 mL) Record total volume and collection time interval on transport tube and test request form.  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Body fluids other than urine.  
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month  
Reference Interval
Test Number Components Reference Interval
Uroporphyrin 0-​4 µmol/mol crt
Heptacarboxylate Porphyrin 0-​2 µmol/mol crt
Coproporphyrin I 0-​6 µmol/mol crt
Coproporphyrin III 0-​14 µmol/mol crt
Porphobilinogen, Urine 0.0-​8.8 µmol/L
Porphobilinogen, Urine (24-​hour) 0.0-​11.0 µmol/d
0020473Creatinine, 24-​Hour Urine
Age Male Female
3-​8 years 140-​700 mg/d 140-​700 mg/d
9-​12 years 300-​1300 mg/d 300-​1300 mg/d
13-​17 years 500-​2300 mg/d 400-​1600 mg/d
18-​50 years 1000-​2500 mg/d 700-​1600 mg/d
51-​80 years 800-​2100 mg/d 500-​1400 mg/d
81 years and older 600-​2000 mg/d 400-​1300 mg/d
Interpretive Data
Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine).

See Compliance Statement B: www.aruplab.com/CS
Note
Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Urine porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittent porphyria (AIP).
CPT Code(s)
84120; 84110
Components
Component Test Code*Component Chart Name
0020207Creatinine, Urine - per volume
0020208Creatinine, Urine - per 24h
0080262Porphobilinogen (PBG), Urine -per volume
0080365Uroporphyrin - ratio to CRT
0080366Heptacarboxylate - ratio to CRT
0080369Porphobilinogen (PBG), Urine -per 24h
0080459Porphyrin Urine Interpretation
0097110Total Volume
0097111Hours Collected
2002059Coproporphyrin I - ratio to CRT
2002061Coproporphyrin III - ratio to CRT
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Coproporphyrin
  • Heptacarboxyl Porphyrin
  • Hexacarboxyl Porphyrin
  • PBG
  • Pentacarboxyl Porphyrin
  • Porphobilinogen
  • Porphyrins, Quantitative, 24-Hour Urine
  • Urine Quantitative
  • Uroporphyrin