Porphyrins and Porphobilinogen (PBG), Urine
2002181
Ordering Recommendation
 
Mnemonic
PORUFPBGU
Methodology
High Performance Liquid Chromatography/Ion Exchange Chromatography/Quantitative Spectrophotometry
Performed
Mon-Fri
Reported
2-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
24-hour or random urine. Refrigerate 24-hour specimens during collection.  
Specimen Preparation
Protect from light. Transfer 8 mL aliquot to an ARUP Amber Transport Tube. (Min: 4 mL) Record total volume and collection time interval on transport tube and test request form.  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Body fluids other than urine.  
Remarks
  
Stability
Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month  
Reference Interval
 
 
Test Number Components Reference Interval
 Uroporphyrin 0-​4 µmol/mol crt
 Heptacarboxylate Porphyrin 0-​2 µmol/mol crt
 Coproporphyrin I 0-​6 µmol/mol crt
 Coproporphyrin III 0-​14 µmol/mol crt
 Porphobilinogen, Urine 0.0-​8.8 µmol/L
 Porphobilinogen, Urine (24-​hour) 0.0-​11.0 µmol/d
0020473Creatinine, 24-​Hour Urine  
 
Age Male Female
3-​8 years 140-​700 mg/d 140-​700 mg/d
9-​12 years 300-​1300 mg/d 300-​1300 mg/d
13-​17 years 500-​2300 mg/d 400-​1600 mg/d
18-​50 years 1000-​2500 mg/d 700-​1600 mg/d
51-​80 years 800-​2100 mg/d 500-​1400 mg/d
81 years and older 600-​2000 mg/d 400-​1300 mg/d
Interpretive Data
Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine).

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Urine porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittent porphyria (AIP).
CPT Code(s)
84120; 84110
Components
Component Test Code*Component Chart Name
0020207Creatinine, Urine - per volume
0020208Creatinine, Urine - per 24h
0080262Porphobilinogen (PBG), Urine -per volume
0080365Uroporphyrin - ratio to CRT
0080366Heptacarboxylate - ratio to CRT
0080369Porphobilinogen (PBG), Urine -per 24h
0080459Porphyrin Urine Interpretation
0097110Total Volume
0097111Hours Collected
2002059Coproporphyrin I - ratio to CRT
2002061Coproporphyrin III - ratio to CRT
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Coproporphyrin
  • Heptacarboxyl Porphyrin
  • Hexacarboxyl Porphyrin
  • PBG
  • Pentacarboxyl Porphyrin
  • Porphobilinogen
  • Porphyrins, Quantitative, 24-Hour Urine
  • Urine Quantitative
  • Uroporphyrin