Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM
2002063
Ordering Recommendation
 
Mnemonic
CRYGB QNT
Methodology
Qualitative Cold Precipitation/Quantitative Nephelometry
Performed
Sun-Sat
Reported
3-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Fasting specimen required.  
Collect
Plain red tube.  
Specimen Preparation
1) Draw approximately 7 mL of blood into a pre-warmed (37 degrees C) plain red tube. Alternatively: draw into a pre-warmed (37 degrees C) syringe and immediately transfer blood to a pre-warmed (37 degrees C) plain red tube. 2) Maintain collected blood at 37 degrees C until clotting is complete (up to 1 hour).  3) Separate serum from cells ASAP. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.  
Unacceptable Conditions
Plasma. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.  
Remarks
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.  
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
 
 
Test Number Components Reference Interval
0050185Cryoglobulin, Qualitative Negative at 72 hours.
 Immunoglobulin A, Cryoprecipitate 0 mg/dL
 Immunoglobulin G, Cryoprecipitate 0 mg/dL
 Immunoglobulin M, Cryoprecipitate 0 mg/dL
Interpretive Data
The sample is examined daily for the presence or absence of cryoglobulin.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.
CPT Code(s)
82595; if reflexed, add 82784 x3
Components
Component Test Code*Component Chart NameLOINC
0050188Cryoglobulin Quantitative Screen12203-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cryoglobulins/cryoglobulins
  • Cryocrit
  • Cryoglobulins reflex test to IgA, IgG, and IgM
  • Cryoprotein
  • Quantitative cryoglobulins