Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM
Ordering Recommendation
Qualitative Cold Precipitation/Quantitative Nephelometry
3-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Fasting specimen required.  
Plain red tube.  
Specimen Preparation
1) Draw approximately 7 mL of blood into a pre-warmed (37 degrees C) plain red tube. Alternatively: draw into a pre-warmed (37 degrees C) syringe and immediately transfer blood to a pre-warmed (37 degrees C) plain red tube. 2) Maintain collected blood at 37 degrees C until clotting is complete (up to 1 hour).  3) Separate serum from cells ASAP. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.  
Unacceptable Conditions
Plasma. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.  
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.  
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
Test Number Components Reference Interval
0050185Cryoglobulin, Qualitative Negative at 72 hours.
 Immunoglobulin A, Cryoprecipitate 0 mg/dL
 Immunoglobulin G, Cryoprecipitate 0 mg/dL
 Immunoglobulin M, Cryoprecipitate 0 mg/dL
Interpretive Data
The sample is examined daily for the presence or absence of cryoglobulin.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.
CPT Code(s)
82595; if reflexed, add 82784 x3
Component Test Code*Component Chart NameLOINC
0050188Cryoglobulin Quantitative Screen12203-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Cryoglobulins/cryoglobulins
  • Cryocrit
  • Cryoglobulins reflex test to IgA, IgG, and IgM
  • Cryoprotein
  • Quantitative cryoglobulins