Neisseria meningitidis Tetravalent Antibodies (Serogroups A, C, W-135 and Y), IgG
Ordering Recommendation
Use to assess immunocompetence following Neisseria meningitidis vaccination. To assess suspected immunodeficiency, use pre- and postvaccination serology. Do not use for diagnosis of infection or serotyping.
Quantitative Multiplex Bead Assay
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)  
Storage/Transport Temperature
Unacceptable Conditions
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
N. meningitidis A, C, W-135 and Y, IgG:
0.9 µg/mL or less: Antibody concentration not protective.
1.0-2.0 µg/mL: Equivocal.
2.1 µg/mL or greater: Antibody to Neisseria meningitidis detected. Suggestive of protection.

Responder status is determined according to the ratio of the one month post-vaccination concentration to pre-vaccination concentration of IgG antibodies to N. meningitidis (Types A, C, Y, and W-135) as follows:

1. If the one month post-vaccination concentration is less than 3.0 µg/mL, the patient is considered to be a non-responder.
2. If the one month post-vaccination concentration is greater than or equal to 3.0 µg/mL, a patient with a ratio of greater than or equal to 4 is a good responder, a ratio of  2-4 is a weak responder, and a ratio of less than 2 is considered a non-responder  
Interpretive Data

See Compliance Statement B:  
CPT Code(s)
86741 x4
Component Test Code*Component Chart Name
2001604N.meningitidis Type A IgG
2001605N.meningitidis Type C IgG
2001606N.meningitidis Type Y IgG
2001607N.meningitidis Type W-135 IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Meningococcal IgG Vaccine Response
  • N. Meningitidis IgG Vaccine Response
  • Neisseria meningitidis
  • Vaccine Resonse