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Renin, Direct
2001575
Ordering Recommendation

The combined aldosterone/renin tests are preferred (refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin, Direct with Ratio (2002582)) for diagnosing hyperaldosteronism.

Mnemonic
RENIND
Methodology
Quantitative Immunoradiometry
Performed
Mon
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Normal sodium diet (100-200 mEq/day) for at least three days. Receiving no medications known to affect renin-aldosterone system.
Supine:
Specimen should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position).
OR
Upright:
Specimen should be obtained before noon (after at least two hours in upright position; seated or standing).
Contact Medical Director if more information is needed. 
Collect
From either a supine or upright patient, Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes. 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens. 
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 4 weeks 
Reference Interval
2.5-45.7 pg/mL
Interpretive Data


Note
Do not use this test for patients treated with Cathepsin B.
CPT Code(s)
84244
Components
Component Test Code*Component Chart NameLOINC
2001576Direct Renin2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Direct Renin