Homocysteine, Total
0099869
Ordering Recommendation
Not recommended for risk assessment of cardiovascular disease or venous thromboembolism.  Acceptable screening test for disorders of methionine metabolism.
Mnemonic
HOMOCY-QNT
Methodology
Quantitative Enzymatic
Performed
Sun-Sat
Reported
Within 24 hours  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Green (lithium heparin) or serum separator tube.  
Specimen Preparation
Serum or plasma must be separated immediately after collection. If immediate centrifugation is not possible, collected blood specimens should be kept on ice and centrifuged within one hour. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Sodium citrate.  
Remarks
  
Stability
Ambient: 4 days; Refrigerated: 1 month; Frozen: 10 months  
Reference Interval
Less than 11 µmol/L, for both male and female  
Interpretive Data
Elevated total homocysteine (tHcy) concentrations may be associated with vitamin B12 deficiency, folate deficiency, or inherited disorders of methionine metabolism. tHcy may also be used as a weak-graded risk factor for cardiovascular disease or stroke.  
Note
False elevations of plasma or serum homocysteine may occur if the plasma or serum is not promptly separated from the cells at the time of collection. Fasting specimen preferred.
CPT Code(s)
83090
Components
Component Test Code*Component Chart NameLOINC
0099869Homocysteine, Total13965-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Plasma Total Homocysteine