Not recommended for risk assessment of cardiovascular disease or venous thromboembolism. Acceptable screening test for disorders of methionine metabolism.
This test is New York DOH approved.
- Patient Preparation
- Fasting specimen preferred.
- Green (lithium heparin) or serum separator tube.
- Specimen Preparation
- Serum or plasma must be separated immediately after collection. If immediate centrifugation is not possible, collected blood specimens should be kept on ice and centrifuged within one hour. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Sodium citrate.
- Ambient: 4 days; Refrigerated: 1 month; Frozen: 10 months
Less than 11 µmol/L, for both male and female
Elevated total homocysteine (tHcy) concentrations may be associated with vitamin B12 deficiency, folate deficiency, or inherited disorders of methionine metabolism. tHcy may also be used as a weak-graded risk factor for cardiovascular disease or stroke.
False elevations of plasma or serum homocysteine may occur if the plasma or serum is not promptly separated from the cells at the time of collection.
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- Plasma Total Homocysteine