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Methylmalonic Acid, Serum or Plasma (Vitamin B12 Status)
0099431
Ordering Recommendation

Use to evaluate vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease. Preferred test is 0055662 (vitamin B12 test reflexes to serum methylmalonic acid).

Mnemonic
MMA QNT-P
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain red or serum separator tube. Also acceptable: Green (sodium heparin), green (lithium heparin), lavender (EDTA), or pink (K2EDTA).  
Specimen Preparation
Centrifuge and remove serum or plasma from cells within 2 hours of collection. Transfer 1.2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 0.6 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Room temperature specimens. Grossly hemolyzed or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month  
Reference Interval
0.00-0.40 µmol/L
Interpretive Data


Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Note
CPT Code(s)
83921
Components
Component Test Code*Component Chart NameLOINC
0099431MMA Serum/Plasma, Vitamin B12 Status13964-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cobalamin Deficiency (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency)
  • Methylmalonate (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency)
  • MMA (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency))
  • Vitamin B12 Deficiency (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency))