Helicobacter pylori Antibody, IgG
Ordering Recommendation
Do not use to diagnose H. pylori; order H. pylori urea breath test (Adults 2010476, Children 2010925) or fecal antigen by EIA (0065147). Use IgG only if breath and/or stool tests cannot be performed.
Semi-Quantitative Enzyme Immunoassay
Within 24 hours  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.1 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
1.7 EV or less: Negative - No significant level of IgG antibody to H. pylori detected.
1.8-2.2 EV: Equivocal - Repeat testing in 10-14 days may be helpful.
2.3 EV or greater: Positive - IgG antibody to H. pylori detected, suggestive of previous exposure or active infection.  
Interpretive Data
Previously known as Campylobacter pylori, Helicobacter pylori-specificantibodies are detectable in almost all adult patients with duodenal ulcer and about 80% of patients with gastric ulcer. The prevalence of H. pylori antibodies increases with age and can be found in a significant percentage of healthy individuals over the age of 50. Positive results do not confirm the diagnosis of H. pylori-associated gastritis or duodenal ulcer, but negative results are strong evidence against these diagnoses.

For additional information, refer to Helicobacter pylori topic at

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0099359Helicobacter pylori Antibody IgG5176-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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