Liver-Kidney Microsome Antibody, IgG
0099270
Ordering Recommendation
Submit With Order
Mnemonic
LIVER-KID
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Mon-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Severely hemolyzed or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Less than 1:20 Normal
Interpretive Data
Liver-Kidney Microsome IgG antibody (anti-LKM), as detected by indirect immunofluorescent antibody (IFA) techniques, may be observed in patients with autoimmune hepatitis type 2 (AIH-2), AIH-2 associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), viral hepatitis C or D, and some forms of drug-induced hepatitis. This IFA does not differentiate among the four types of LKM antibodies (LKM-1, LKM-2, LKM-3, and a fourth type that recognizes CYP1A2 and CYP2A6 antigens). Of these, anti-LKM-1 (cytochrome P450IID6) IgG antibodies are considered specific for AIH-2.

See Compliance Statement D: www.aruplab.com/CS
Note
CPT Code(s)
86376
Components
Component Test Code*Component Chart Name
0099270Liver-Kidney-Microsome Abs, IgG by IFA
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Cross References
  • Antibodies to Liver\Kidney Microsome Type 1, Serum
  • Liver-Kidney Microsome-1 Antibody, IgG
  • LKM IgG Antibodies
  • LKM1 antibodies
  • LKM1 IgG
  • MicrosomalType 1 Ab